148017-39-4

Basic information

• Product Name: (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• Synonyms: (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
• CAS NO: 148017-39-4
• Molecular Formula: C12H21NO4S
• Molecular Weight: 275.36444
• Mol File: 148017-39-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 388.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 14.77±0.10(Predicted)
• CAS DataBase Reference: (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate(148017-39-4)
• EPA Substance Registry System: (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate(148017-39-4)

Safety Data

• Hazardous Substances Data: 148017-39-4(Hazardous Substances Data)

Usage

General Description

The chemical (2S,4R)-tert-butyl 4-(acetylthio)-2-(hydroxymethyl)pyrrolidine-1-carboxylate is a complex compound with a molecular formula of C13H23NO4S. It belongs to the class of organic compounds known as N-acyl alpha amino acids and derivatives, and it is used in the synthesis of pharmaceutical drugs and other organic compounds. The compound has a pyrrolidine skeleton and contains a tert-butyl group, an acetylthio group, and a hydroxymethyl group. It is typically synthesized in laboratory settings for research purposes and has potential applications in drug development and organic chemistry.

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 148017-37-2 (2S,4S)-1-t-butoxycarbonyl-4-formyloxy-2-methoxycarbonylpyrrolidine 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 148017-38-3 tert-butyl (2S,4S)-2-(hydroxymethyl)-4-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate 
• 10387-40-3 potassium thioacetate 

Downstream Products

• 148090-79-3 C₃₈H₅₀N₄O₁₀S₂ 

Relevant articles and documents

Synthesis and modification of a novel 1 β-methyl carbapenem antibiotic, S-4661

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.