148018-29-5

Basic information

• Product Name: 4-Chloro-6-hydroxyquinoline
• Synonyms: 4-Chloro-6-hydroxyquinoline;4-Chloroquinolin-6-ol
• CAS NO: 148018-29-5
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.60304
• EINECS: -0
• Mol File: 148018-29-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 304.939 °C at 760 mmHg
• Flash Point: 138.222 °C
• Appearance: /
• Density: 1.412 g/cm³
• Vapor Pressure: 0.00047mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Chloro-6-hydroxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-hydroxyquinoline(148018-29-5)
• EPA Substance Registry System: 4-Chloro-6-hydroxyquinoline(148018-29-5)

Safety Data

• Hazardous Substances Data: 148018-29-5(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-hydroxyquinoline is a chemical compound that belongs to the class of quinoline derivatives. It is a chlorinated hydroxyquinoline with the molecular formula C9H6ClNO. This chemical is commonly used in the production of pharmaceuticals, agrochemicals, and dyes. It has antibacterial and antifungal properties, making it a valuable component in the formulation of various types of medications and disinfectants. Additionally, 4-Chloro-6-hydroxyquinoline has been studied for its potential applications in treating various medical conditions, including infectious diseases and cancer. Due to its therapeutic properties and versatile applications, this chemical compound is widely used in the pharmaceutical and chemical industries.

InChI:InChI=1/C9H6ClNO/c10-8-3-4-11-9-2-1-6(12)5-7(8)9/h1-5,12H

Upstream product

• 4295-04-9 4-chloro-6-methoxyquinoline 
• 23432-39-5 4-hydroxy-6-methoxyquinoline 
• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 83507-70-4 diethyl 2-(((4-methoxyphenyl)amino)methylene)malonate 
• 28027-16-9 4-hydroxy-6-methoxy-3-quinoline carboxylic acid 
• 871876-07-2 4-amino-quinolin-6-ol 

Relevant articles and documents

Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model

This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7 nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat, dog and monkey).

THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS

Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.

CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF

Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification.