14804-46-7Relevant academic research and scientific papers
Synthesis of 6-epi-tuberiferin and the biological activities of tuberiferin, dehydrobrabrachylaenolide, 6-epi-tuberiferin, and their synthetic intermediates
Li, Dan,Higuchi, Yohsuke,Kobayashi, Takafumi,Shimoma, Fumito,Bai, Yuhua,Ando, Masayoshi
supporting information, (2021/02/02)
Tuberiferin, 6-epi-tuberifelin, dehydrobrachylaenolide and two series of eudesmanolides, eudesmane-12,6 α-lactones and eudesmane-12,6β-lactones, were synthesized for the studies of the structure–activity relationships to explore novel anti-inflammatory, a
Synthesis of a structurally constrained endoperoxide having antimalarial activity from α-santonin
Van Der Westhuyzen,Parkinson
, p. 41 - 45 (2007/10/03)
α-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity.
