1480436-97-2Relevant academic research and scientific papers
Copper-granule-catalyzed microwave-assisted click synthesis of polyphenol dendrimers
Lee, Choon Young,Held, Rich,Sharma, Ajit,Baral, Rom,Nanah, Cyprien,Dumas, Dan,Jenkins, Shannon,Upadhaya, Samik,Du, Wenjun
, p. 11221 - 11228 (2013/12/04)
Syringaldehyde- and vanillin-based antioxidant dendrimers were synthesized via microwave-assisted alkyne-azide 1,3-dipolar cycloaddition using copper granules as a catalyst. The use of Cu(I) as a catalyst resulted in copper contaminated dendrimers. To produce copper-free antioxidant dendrimers for biological applications, Cu(I) was substituted with copper granules. Copper granules were ineffective at both room temperature and under reflux conditions (50 values of less than 3 μM in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. In comparison, dendrimers synthesized from Cu(I)-catalyzed click chemistry showed a high level of copper contamination (4800 ppm) and no detectable antioxidant activity.
