1246672-86-5Relevant academic research and scientific papers
Effect of electron donating groups on polyphenol-based antioxidant dendrimers
Lee, Choon Young,Nanah, Cyprien N.,Held, Rich A.,Clark, Amanda R.,Huynh, Uyen G.T.,Maraskine, Marina C.,Uzarski, Rebecca L.,McCracken, John,Sharma, Ajit
, p. 125 - 134 (2015)
Numerous studies have reported the beneficial effects of antioxidants in human diseases. Among their biological effects, a majority of antioxidants scavenge reactive radicals in the body, thereby reducing oxidative stress that is associated with the patho
Copper-granule-catalyzed microwave-assisted click synthesis of polyphenol dendrimers
Lee, Choon Young,Held, Rich,Sharma, Ajit,Baral, Rom,Nanah, Cyprien,Dumas, Dan,Jenkins, Shannon,Upadhaya, Samik,Du, Wenjun
, p. 11221 - 11228 (2013/12/04)
Syringaldehyde- and vanillin-based antioxidant dendrimers were synthesized via microwave-assisted alkyne-azide 1,3-dipolar cycloaddition using copper granules as a catalyst. The use of Cu(I) as a catalyst resulted in copper contaminated dendrimers. To produce copper-free antioxidant dendrimers for biological applications, Cu(I) was substituted with copper granules. Copper granules were ineffective at both room temperature and under reflux conditions (50 values of less than 3 μM in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. In comparison, dendrimers synthesized from Cu(I)-catalyzed click chemistry showed a high level of copper contamination (4800 ppm) and no detectable antioxidant activity.
