148062-66-2

Usage

Structure

A five-membered heterocyclic ring containing three nitrogen atoms and two carbon atoms, with a triphenylmethyl (trityl) group attached to the 1-position and a carboxaldehyde group at the 3-position.

Usage

Commonly used as a building block in organic synthesis to create various pharmaceuticals, agrochemicals, and other fine chemicals.

Biological activity

Exhibits anti-tumor and anti-inflammatory activities, making it an important compound in medicinal chemistry research.

Protecting group

The triphenylmethyl (trityl) group can act as a protecting group in organic synthesis, aiding in the formation of various functional groups.

Upstream product

• 146097-08-7 1-trityl-1H-1,2,4-triazole-5-carbaldehyde 

Downstream Products

• 148062-67-3 [3-hydroxy-3-(1-trityl-1H-[1,2,4]triazol-3-yl)-prop-1-ynyl]-phosphonic acid diethyl ester 
• 151297-38-0 3-trimethylsilanyl-1-(1-trityl-1H-[1,2,4]triazol-3-yl)-prop-2-yn-1-ol 
• 156332-57-9 [2-oxo-3-(1-trityl-1H-[1,2,4]triazol-3-yl)-propyl]-phosphonic acid diethyl ester 
• 156332-58-0 [2-hydroxy-3-(1-trityl-1H-[1,2,4]triazol-3-yl)-propyl]-phosphonic acid diethyl ester 
• 194359-84-7 [3-(1-trityl-1H-[1,2,4]triazol-3-yl)-propa-1,2-dienyl]-phosphonic acid diethyl ester 
• 156332-56-8 3(1-trityl-1,2,4-triazol-3-yl)prop-1-yn-3-ol 

Relevant academic research and scientific papers

Method for synthesizing 1 - methyl - 1H -1, 2 and 4 - triazol -3 - methyl formate

The invention discloses a synthetic 1 - methyl - 1H -1. The invention discloses a method for 2,4 - triazole -3 - methyl formate and belongs to the technical field of organic synthesis. The reaction of 1,2 and 4 - triazole as a raw material is followed by

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

The design and synthesis of inhibitors of imidazoleglycerol phosphate dehydratase as potential herbicides

The discovery and exploration of a new class of broad-spectrum postemergent herbicides with a novel mode of action, namely the disruption of histidine biosynthesis via inhibition of imidazoleglycerol phosphate dehydratase (IGPD; E.C. 4.2.1.19), are described. Clear structural similarities between the first member, produced during an attempt to produce analogues of glyphosate, and intermediates in histidine biosynthesis were noted. Several series of targets were designed, to mimic both the enzyme substrate and a putative reaction intermediate, and synthesised. Some examples were found to be both extremely potent inhibitors of the enzyme, having K(i) values as low as 0·3 nM, and phloem-mobile herbicides with levels of weed control similar to those shown by glyphosate. Further logical progress awaits a high-resolution X-ray structure determination of an enzyme-inhibitor complex.

Triazole phosphoric acid derivatives and their use as herbicides

A herbicidal compound of formula (I) STR1 or a salt, tautomer or cyclic derivative thereof; where R1 and R2 are hydrogen and A is an optionally substituted saturated or unsaturated chain or ring of three carbon atoms. Methods for pre