14814-55-2Relevant academic research and scientific papers
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation
Fioravanti, Rossella,Romanelli, Annalisa,Mautone, Nicola,Di Bello, Elisabetta,Rovere, Annarita,Corinti, Davide,Zwergel, Clemens,Valente, Sergio,Rotili, Dante,Botrugno, Oronza A.,Dessanti, Paola,Vultaggio, Stefania,Vianello, Paola,Cappa, Anna,Binda, Claudia,Mattevi, Andrea,Minucci, Saverio,Mercurio, Ciro,Varasi, Mario,Mai, Antonello
, p. 643 - 658 (2020/02/18)
Abstract: LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill its large catalytic cleft by designing tranylcypromine (TCP) analogs decorated with long,
