148147-40-4Relevant academic research and scientific papers
Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative
Kawai, Megumi,Gunawardana, Indrani W. K.,Mollison, Karl W.,Hsieh, Gin C.,Lane, Benjamin C.,Luly, Jay R.
, p. 935 - 938 (1998)
Ascomycin 2, a close analogue of the immunosuppressant FK506 1, was modified to incorporate a hydroxyl group at the C-33 position. This increased the aqueous solubility of ascomycin by a hundred-fold at pH 7.4 and by approximately 300-fold at pH 6.5. Ascomycin 3 also exhibited an excellent immunosuppressive activity in vitro, as tested in a human mixed lymphocyte proliferation (HuMLR) assay, and in vivo using a rat popliteal lymph node (rPLN) hyperplasia assay.
