Bioorganic and Medicinal Chemistry Letters p. 935 - 938 (1998)
Update date:2022-08-03
Topics:
Kawai, Megumi
Gunawardana, Indrani W. K.
Mollison, Karl W.
Hsieh, Gin C.
Lane, Benjamin C.
Luly, Jay R.
Ascomycin 2, a close analogue of the immunosuppressant FK506 1, was modified to incorporate a hydroxyl group at the C-33 position. This increased the aqueous solubility of ascomycin by a hundred-fold at pH 7.4 and by approximately 300-fold at pH 6.5. Ascomycin 3 also exhibited an excellent immunosuppressive activity in vitro, as tested in a human mixed lymphocyte proliferation (HuMLR) assay, and in vivo using a rat popliteal lymph node (rPLN) hyperplasia assay.
View MoreShenyang NovPharm Technology Co., Ltd.
Contact:.+86-24-24165786
Address:Room 306, Hongjin Mansion, No. 36-1, Wanliutang Rd., Shenhe District, Shenyang, Liaoning, P.R.C.
Jintan City Mego Chemical Co., Ltd
Contact:+86-0519-82814387
Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Shanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd
Contact:+86-0372-3662335 +86-0372-3661988
Address:hanling industrial park anyang
Contact:86-931-8272767
Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
SHANDONG AONA CHEMICAL CO.,LTD.
Contact:86-532-85762926
Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
Doi:10.1021/ja00063a013
(1993)Doi:10.1039/c9sc05111b
(2020)Doi:10.1021/ol4031028
(2013)Doi:10.1021/om400932g
(2013)Doi:10.1002/ejoc.202100174
(2021)Doi:10.1007/BF00529579
(1992)