14815-86-2Relevant articles and documents
Synthesis method of o-trifluoromethyl methyl benzoate, m-trifluoromethyl methyl benzoate and p-trifluoromethyl methyl benzoate
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Paragraph 0017, (2018/03/01)
The invention provides a synthesis method of o-trifluoromethyl methyl benzoate, m-trifluoromethyl methyl benzoate and p-trifluoromethyl methyl benzoate. The synthesis method comprises the following steps: taking methyl benzoic acid as a raw material, carrying out acylating chlorination to obtain methylbenzoyl chloride, carrying out side-chain chlorination to obtain trichloromethyl benzoyl chloride, carrying out fluorination substitution to obtain trifluoromethyl benzoyl fluoride, and carrying out esterification to obtain a final product which is trifluoromethyl methyl benzoate. The synthesis method can be used for producing the o-trifluoromethyl methyl benzoate, the m-trifluoromethyl methyl benzoate and the p-trifluoromethyl methyl benzoate, is easily available in raw material, mild in reaction mechanism, high in reaction yield, few in reaction by-products, low in yield of three wastes and easy in treatment of three wastes, and is suitable for industrial production.
Preparation of substituted benzotrichlorides
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, (2008/06/13)
A process for chlorinating a compound of the formula STR1 in which R1 is a C1 -alkyl radical, C1 -alkoxy radical or C1 -thioalkyl radical, and X1, X2, X3 and X4 are identical or different hydrogen or halogen, and X3 may alternatively be STR2 or --NCO, comprising, in an initial phase, dissolving a chlorination catalyst in the compound to be chlorinated, continuously metering this solution together with chlorine into a reaction vessel containing the compound to be chlorinated, and, after the initial phase, removing partially or fully chlorinated compounds from the reaction vessel, dissolving fresh chlorination catalyst in the removed compounds, and feeding this catalyst solution, together with chlorine, to the reaction vessel.
Preparation and screening of some new thioacetals, sulfones, and derivatives of 4-dichloromethylbenzoyl and 4-trichloromethylbenzoyl chloride as potential antimalarials
Morkved,Cronyn
, p. 59 - 63 (2007/10/02)
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