148182-98-3Relevant academic research and scientific papers
Synthesis of tryptanthrin (couroupitine) derivatives by reaction of substituted isatins with phosphoryl chloride
Moskovkina,Kalinovskii,Makhan'kov
, p. 123 - 126 (2012)
Reaction of 5-methyl-, 5-bromo-, and 5-iodoisatins with phosphoryl chloride gave the corresponding 2,8-disubstituted indolo[2,1-b]quinazoline-6,12-diones in moderate yield. 5,7-Dichloroisatin failed to react with POCl3. Treatment of an equimolar mixture of isatin and 5-bromoisatin with POCl3 afforded indolo[2,1-b]-quinazoline-6,12-dione (tryptanthrin), 2,8-dibromoindolo[2,1-b] quinazoline-6,12-dione, and two isomeric monobromo-substituted tryptanthrin derivatives, the 2-bromo isomer prevailing. Pleiades Publishing, Ltd., 2012.
