148225-52-9

Basic information

• Product Name: 1-[(3R,3aS,5aR,6R,9bS)-6-Hydroxy-5a-methyl-9-methylene-2-oxoperhydronaphtho[1,2-b]furan-3-ylmethyl]pyrrolidine-2(S)-carboxylic acid
• Synonyms: Saussureamine E
• CAS NO: 148225-52-9
• Molecular Formula: C₂₀H₂₉NO₅
• Molecular Weight: 363.45783
• Mol File: 148225-52-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[(3R,3aS,5aR,6R,9bS)-6-Hydroxy-5a-methyl-9-methylene-2-oxoperhydronaphtho[1,2-b]furan-3-ylmethyl]pyrrolidine-2(S)-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(3R,3aS,5aR,6R,9bS)-6-Hydroxy-5a-methyl-9-methylene-2-oxoperhydronaphtho[1,2-b]furan-3-ylmethyl]pyrrolidine-2(S)-carboxylic acid(148225-52-9)
• EPA Substance Registry System: 1-[(3R,3aS,5aR,6R,9bS)-6-Hydroxy-5a-methyl-9-methylene-2-oxoperhydronaphtho[1,2-b]furan-3-ylmethyl]pyrrolidine-2(S)-carboxylic acid(148225-52-9)

Safety Data

• Hazardous Substances Data: 148225-52-9(Hazardous Substances Data)

Upstream product

• 29424-04-2 (+)-reynosin 
• 147-85-3 L-proline 

Relevant articles and documents

Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa

From the methanolic extract of the dried roots of Saussurea lappa Clarke, Saussureae Radix, five amino acid-sesquiterpene conjugates, saussureamines A, B, C, D and E, were isolated together with a lignan glycoside, (-)-massoniresinol 4-O-β-D-glucopyranoside. Their stereostructures were determined on the basis of chemical and physicochemical evidence. In addition, saussureamines and the related amino acid-sesquiterpene conjugates were synthesized using a Michael type addition reaction of amino acid to the α-methylene-γ-lactone moiety of sesquiterpenes. Saussureamines A, B and C, costunolide and dehydrocostus lactone showed a gastroprotective effect on acidified ethanol-induced gastric mucosal lesions in rats. Saussureamines A also exhibited an inhibitory effect on gastric mucosal lesions induced by water-immersion stress in mice. (C) 2000 Elsevier Science Ltd.