1482348-49-1

Basic information

• Product Name: (κ²-O,O-kaempferol)(κ²-N,N-2,2'-bipyridine)copper(II) chloride
• Synonyms: (κ²-O,O-kaempferol)(κ²-N,N-2,2'-bipyridine)copper(II) chloride
• CAS NO: 1482348-49-1
• Molecular Weight: 558.434
• Mol File: 1482348-49-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (κ²-O,O-kaempferol)(κ²-N,N-2,2'-bipyridine)copper(II) chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (κ²-O,O-kaempferol)(κ²-N,N-2,2'-bipyridine)copper(II) chloride(1482348-49-1)
• EPA Substance Registry System: (κ²-O,O-kaempferol)(κ²-N,N-2,2'-bipyridine)copper(II) chloride(1482348-49-1)

Safety Data

• Hazardous Substances Data: 1482348-49-1(Hazardous Substances Data)

Upstream product

• 366-18-7 [2,2]bipyridinyl 
• 520-18-3 kaempferol 

Relevant articles and documents

Synthesis, characterization, DNA interaction, and antitumor activities of mixed-ligand metal complexes of kaempferol and 1,10-phenanthroline/2,2′- bipyridine

Four novel mixed-ligand metal complexes with the composition [Cu(Kae)(phen)]Cl·2H2O (1), [Cu(Kae)(bpy)]Cl·H 2O ( 2), [Zn(Kae)(phen)]Cl·H2O (3), and [Zn(Kae)(bpy)]Cl·H2O (4), where Kae = kaempferol, phen = 1,10-phenanthroline, bpy = 2,2′-bipyridine were synthesized and characterized by elemental analysis, IR, UV, 1H NMR, 13C NMR, HRMS ,and molar conductivity. The binding and cleavage abilities of complexes 1-4 with DNA have been studied by fluorescence spectroscopy, viscosity measurements, and gel electrophoresis under physiological conditions. The experimental results indicated that four complexes could bind to CT-DNA via an intercalative mode, and the complex 1 showed the strongest activity to cleavage DNA (pUC 19). The in vitro cytotoxicities of kaempferol and complexes 1-4 were also evaluated against human breast carcinoma cells by MTT assays. The results show that the cytotoxicities of complexes 1-4 are much higher than that of kaempferol alone, and the complex 1 shows the strongest ability to inhibit the growth of human breast carcinoma cells. The results suggest that the complex 1 may be a valuable tool in cancer chemotherapy agents. Springer Science+Business Media 2013.