148238-28-2Relevant articles and documents
Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides
Xin, Xiaoqing,Xiang, Dexuan,Yang, Jiming,Zhang, Qian,Zhou, Fenguo,Dong, Dewen
, p. 11956 - 11961 (2013)
A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.
Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles
Liu, Yingtian,Dang, Xinxin,He, Yu,Bai, Hudong,Chen, Xuehong,Li, Jun-Long,Fan, Junting,Jiang, Hezhong,Li, Jiahong
, p. 662 - 671 (2019/02/20)
A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit
A 'Biogenetic Like' Synthesis of Perloline, 6-(3,4-dimethoxyphenyl)-5-hydroxy-5,6-dihydrobenzonaphthyridin-4(3H)-one
Duong, Thach,Prager, Rolf H.,Were, Stephen T.
, p. 1431 - 1440 (2007/10/02)
9H-Indenopyridine-1(2H),9-dione, prepared by a new efficient route, reacts with 3,4-dimethoxyphenyllithium to form the keto alcohol (7), which rearranges with hydrazoic acid to form 5-(3,4-dimethoxyphenyl)benznaphthyridin-4(3H)-one.The N-oxide photolyses smoothly to yield dehydroperloline as the sole product.
