1483-19-8

Upstream product

• 1483-20-1 5-methoxybenzo[d][1,3]oxathiol-2-one 
• 66582-92-1 3-methoxy-2-hydroxyphenyl disulfide 
• 150-76-5 4-methoxy-phenol 
• 106-51-4 p-benzoquinone 
• 7735-56-0 5-hydroxybenzo[d][1,3]oxathiol-2-one 

Downstream Products

• 112632-27-6 methyl 2-(1-ethoxycarbonylethyl)thio-4-methoxyphenoxyacetate 
• 1483-18-7 4-methoxy-2-(methylthio)phenol 
• 1616377-41-3 4-(6-methoxybenzo[1,4]oxathiin-2-yl)phenol 
• 1616377-45-7 C₁₅H₁₄O₄S 
• 112632-32-3 dimethyl 2-(4-methoxy-2-methoxycarbonylmethylthiophenyloxy)glutarate 
• 112632-52-7 7-Methoxy-2-phenyl-11H-10-oxa-5-thia-1,3-diaza-dibenzo[a,d]cyclohepten-4-ylamine 
• 112632-31-2 methyl 5-methoxy-2-(2-oxo-tetrahydrofuryloxy)phenylthioacetate 
• 112632-30-1 methyl 2-cyanomethyloxy-5-methoxyphenylthioacetate 
• 99013-56-6 methyl 2-N,N-diethylcarbamoylmethylthio-4-methoxyphenoxyacetate 
• 99013-54-4 methyl 4-methoxy-2-methoxycarbonylmethylthiophenoxyacetate 
• 112632-28-7 methyl 2-hydroxy-5-methoxyphenylthioacetate 
• 112632-48-1 methyl 2-cyanomethylthio-4-methoxyphenoxyacetate 
• 99013-58-8 2-cyanomethylthio-4-methoxyphenoxyacetonitrile 
• 83904-42-1 2-(2-mercapto-4-methoxy-phenoxy)-5-methoxy-1,3,2-benzoxathiaborol 

Relevant academic research and scientific papers

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene moiety and are further improved by the electron-donating group attaching to thiaflavan skeleton. It can be concluded that the ferrocene moiety plays the major role for thiaflavans to be antioxidants even in the absence of phenolic hydroxyl groups. On the other hand, the antioxidant effectiveness of phenolic hydroxyl groups in thiaflavans can be improved by the electron-donating group. The influences of sulfur and oxygen atoms in thiaflavans on the antioxidant property of para-hydroxyl group exhibit different manners when the thiaflavans are used to trap radicals and to inhibit DNA oxidation.

NOVEL BENZOXATHIIN DERIVATIVE

Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent -CH-, a nitrogen atom or the like.

Regiocontrolled carbonylsulfanylations at ortho-position of phenols and at α-position of ketones using chlorocarbonylsulfenyl chloride

Bu3N/AlCl3-promoted [3+2] cyclocondensation between phenols and chlorocarbonylsulfenyl chloride (CCSC; 3) gave 1,3-benzoxathiol-2-ones (2), wherein the acylation of phenols with CCSC (3) and the intramolecular and regioselective ortho-sulfenylation successively proceeded in a one-pot manner. 2-Sulfanylphenols (1) were produced from 2 by mild hydrolysis using NaOH. An analogous Bu3N-promoted [3+2] cyclocondensation between ketones and 3 gave 1,3-oxathioles (7), wherein the α-CH2- position of the ketones was regioselectively sulfenylated.

Synthesis of Aminomethyl Derivatives of 2-Hydroxy-5-methoxythiophenol

Reacting p-methoxyphenol with sulfur monochloride we obtained 2-hydroxy-5-methoxythiophenol. The latter yields by Mannich reaction with formaldehyde and secondary amines aminomethyl derivatives of 2-hydroxy-5-methoxythiophenol.