7735-56-0

Usage

Uses

Used in Organic Synthesis:
5-HYDROXY-1,3-BENZOXATHIOL-2-ONE is used as a coupling reagent for facilitating the formation of amide bonds in peptide synthesis. Its high reactivity and efficiency in improving the coupling process make it a valuable component in this application.
Used in Dye and Pigment Industry:
5-HYDROXY-1,3-BENZOXATHIOL-2-ONE is used as a stabilizer for certain dyes and pigments, enhancing their performance and longevity in various applications.
Used in Metal Industry:
5-HYDROXY-1,3-BENZOXATHIOL-2-ONE is used as a corrosion inhibitor, playing a critical role in protecting metal surfaces from degradation and extending their service life.

InChI:InChI=1/C7H4O3S/c8-4-1-2-5-6(3-4)11-7(9)10-5/h1-3,8H

Upstream product

• 127-09-3 sodium acetate 
• 6274-93-7 S-(2,5-dihydroxy-phenyl)-isothiourea; hydrochloride 
• 64-19-7 acetic acid 
• 17356-08-0 thiourea 
• 106-51-4 p-benzoquinone 
• 123-31-9 hydroquinone 

Downstream Products

• 82531-06-4 5-acetoxy-benzo[1,3]oxathiol-2-one 
• 2889-61-4 2-mercaptobenzene-1,4-diol 
• 55635-34-2 N'-Isopropylidene-hydrazinecarbothioic acid S-(2,5-dihydroxy-phenyl) ester 
• 55635-36-4 C₁₁H₁₄N₂O₃S 
• 55635-35-3 C₁₄H₁₂N₂O₃S 
• 55635-44-4 C₁₄H₁₁N₃O₅S 
• 321974-15-6 5-benzyloxybenzo[d][1,3]oxathiol-2-one 
• 557-40-4 Allyl ether 
• 1616377-45-7 C₁₅H₁₄O₄S 
• 1616377-44-6 C₂₁H₁₈O₃S 
• 110645-14-2 4-(benzyloxy)-2-mercaptophenol 
• 1483-19-8 2-mercapto-4-methoxyphenol 
• 1616377-41-3 4-(6-methoxybenzo[1,4]oxathiin-2-yl)phenol 
• 1616377-40-2 2-phenylbenzo[1,4]oxathiin-6-ol 

Relevant academic research and scientific papers

Sulfur Tuning of [1,3]-Dioxolo[4.5-f]benzodioxole (DBD) Fluorescent Dyes

The replacement of oxygen by sulfur atoms of [1,3]-dioxolo[4.5-f]benzodioxole (DBD) fluorescent dyes is an efficient way to adjust the photophysical properties (sulfur tuning). While previously developed S4-DBD dyes exhibit considerably red-shifted absorption and emission wavelength, the heavy atom effect of four sulfur atoms cause low fluorescence quantum yields and short fluorescence lifetimes. Herein, we demonstrate that the replacement of less than four sulfur atoms (S1-DBD, 1,2-S2-DBD, and 1,4-S2-DBD dyes) permits a fine-tuning of the photophysical properties. In some cases, a similar influence on the wavelength without the detrimental effect on the quantum yields and lifetimes is observed. Furthermore, the synthetic accessibility of S1- and S2-DBD dyes is improved, compared with S4-DBD dyes. For coupling with biomolecules a series of reactive derivatives of the new dyes were developed (azides, OSu esters, alkynes, maleimides).

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene moiety and are further improved by the electron-donating group attaching to thiaflavan skeleton. It can be concluded that the ferrocene moiety plays the major role for thiaflavans to be antioxidants even in the absence of phenolic hydroxyl groups. On the other hand, the antioxidant effectiveness of phenolic hydroxyl groups in thiaflavans can be improved by the electron-donating group. The influences of sulfur and oxygen atoms in thiaflavans on the antioxidant property of para-hydroxyl group exhibit different manners when the thiaflavans are used to trap radicals and to inhibit DNA oxidation.

ESTROGEN RECEPTOR MODULATORS

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or preven

Synthesis of Mercapturic Acid Derivatives of Putative Toxic Metabolites of Bromobenzene

The synthesis and characterization of nine isomerically defined S-arylmercapturic acids of interest in connection with the metabolism of the model hepatotoxin bromobenzene is described.Included are three S-(bromophenyl)-, two S-(bromohydroxyphenyl)-, and three S-(bromodihydroxyphenyl)mercapturic acids of defined substitution pattern.In addition, several related compounds with two or no bromine atoms are described.These syntheses depend on two basic methods, 1,4-addition of various arene thiols to acetamidoacrylic acid or the 1,4-addition of N-acetyl-L-cysteine to various benzoquinone derivatives.In addition, we describe a method for efficient conversion of the mercapturic acids to thioanisole derivatives, regioisomers of which can be separed and detected at low levels by capillary gas-liquid chromatography.