1483-44-9

Usage

Uses

Used in Pharmaceutical Production:
2,5-Dicyanobenzotrifluoride is used as a key intermediate in the synthesis of pharmaceuticals, leveraging its electron-withdrawing properties to facilitate specific chemical reactions that are crucial in drug development.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,5-Dicyanobenzotrifluoride is employed as a reagent for the production of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Dye Manufacturing:
2,5-DICYANOBENZOTRIFLUORIDE is also utilized in the dye industry as a building block for synthesizing novel dyes, taking advantage of its unique chemical structure to produce dyes with specific properties.
Used as a Solvent in Chemical Reactions:
2,5-Dicyanobenzotrifluoride serves as a solvent in certain chemical processes, where its particular characteristics can enhance the efficiency or selectivity of the reactions.
Used in Specialty Chemicals Production:
As an intermediate, 2,5-Dicyanobenzotrifluoride is involved in the production of specialty chemicals, which may have applications in various industries such as plastics, coatings, or materials science.
Safety Note:
It is important to handle 2,5-Dicyanobenzotrifluoride with care, as it is classified as a hazardous chemical. Exposure may result in irritation to the skin, eyes, and respiratory system, necessitating proper safety measures during its use and storage.

InChI:InChI=1/C8H3BrF3N/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-3H

Upstream product

• 623-26-7 terephthalonitrile 
• 76-05-1 trifluoroacetic acid 
• 14353-88-9 iodopentafluorobenzene bis(trifluoroacetate) 
• 2926-29-6 Langlois reagent 

Relevant academic research and scientific papers

Photoinduced Trifluoromethylation of Arenes and Heteroarenes Catalyzed by High-Valent Nickel Complexes

We describe a series of air-stable NiIII complexes supported by a simple, robust naphthyridine-based ligand. Access to the high-valent oxidation state is enabled by the CF3 ligands on the nickel, while the naphthyridine exhibits either a monodentate or bidentate coordination mode that depends on the oxidation state and sterics, and enables facile aerobic oxidation of NiII to NiIII. These NiIII complexes act as efficient catalysts for photoinduced C(sp2)?H bond trifluoromethylation reactions of (hetero)arenes using versatile synthetic protocols. This blue LED light-mediated catalytic protocol proceeds via a radical pathway and demonstrates potential in the late-stage functionalization of drug analogs.

Visible-Light photoredox decarboxylation of perfluoroarene iodine(III) Trifluoroacetates for C-H trifluoromethylation of (Hetero)arenes

A scalable and operationally simple decarboxylative trifluoromethylation of (hetero)arenes with easily accessible C6F5I(OCOCF3)2 under photoredox catalysis has been developed. This method is tolerant of various (hetero)arenes and functional groups. Notably, C6F5I is recycled from the decarboxylation reaction and further used for the preparation of C6F5I(OCOCF3)2. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the application of trifluoroacetic acid in trifluoromethylation reactions.

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).