148404-29-9Relevant academic research and scientific papers
Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2
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, (2019/03/30)
The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B
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, (2015/04/15)
Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. Such diseases include, without limitation, neurological dysfunction such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and seizure disorders; emotional disorders; depression; bipolar disorder; obsessive-compulsive disorder; and other anxiety disorders.
PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF
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Paragraph 0403-0405, (2014/11/27)
The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrole six-membered herteroaryl ring derivative as r
PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF
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Paragraph 0230, (2014/11/11)
The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrol six-membered herteroaryl ring derivative as re
Studies of the solid-phase Pauson-Khand reaction: Selective in-situ enone reduction to 3-azabicyclo[3.3.0] octanones
Becker, Daniel P.,Flynn, Daniel L.
, p. 2087 - 2090 (2007/10/02)
The Smit-Caple DSAC Pauson-Khand cyclization of a series of N-protected allyl propargyl amines in the absence of oxygen gave rise to formation of the saturated azabicyclo[3.3.0]octanones in excellent yields. Standard cyclization in air gave mixtures of sa
