148436-63-9

Basic information

• Product Name: AH 13205
• Synonyms: trans-2-(4-(1-hydroxyhexyl)phenyl-5-oxocyclopentaneheptanoic acid
• CAS NO: 148436-63-9
• Molecular Formula: C24H36O4
• Molecular Weight: 388.544
• Product Categories: Aliphatics, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 148436-63-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 574.1°Cat760mmHg
• Flash Point: 315.1°C
• Appearance: pale yellow/oil
• Density: 1.075g/cm³
• Vapor Pressure: 5.06E-14mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: −20°C
• Solubility: DMSO: >10 mg/mL
• CAS DataBase Reference: AH 13205(CAS DataBase Reference)
• NIST Chemistry Reference: AH 13205(148436-63-9)
• EPA Substance Registry System: AH 13205(148436-63-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 148436-63-9(Hazardous Substances Data)

Usage

Uses

AH 13205 is a selective prostanoid EP2-receptor agonist and is known to exhibit neuroprotective properties.

InChI:InChI=1/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)/t20-,21-,22?/m1/s1

Upstream product

• 836643-56-2 [1-(4-bromo-phenyl)-hexyloxy]-tert-butyl-dimethyl-silane 
• 41138-69-6 7-{3-[(tert-butyldimethylsilanyl)oxy]-5-oxocyclopent-1-en-1-yl}heptanoic acid methyl ester 
• 951401-85-7 C₃₇H₆₆O₅Si₂ 
• 951401-86-8 C₃₁H₅₀O₄Si 
• 836643-57-3 3-(4-(1-(t-butyldimethylsilyloxy)hexyl)phenyl)-2-(7-(4-(methoxy)benzyloxy)heptyl)cyclopentan-1-ol 
• 836643-58-4 3-(4-(1-(t-butyldimethylsilyloxy)hexyl)phenyl)-2-(7-(hydroxy)heptyl)cyclopentan-1-ol 
• 836643-55-1 Acetic acid (1S,4S)-4-{4-[1-(tert-butyl-dimethyl-silanyloxy)-hexyl]-phenyl}-cyclopent-2-enyl ester 
• 836643-54-0 4-(4-(1-(t-butyldimethylsilyloxy)hexyl)phenyl)-2-cyclopenten-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 
• 693-25-4 n-pentylmagnesium bromide 
• 60176-77-4 (1S,4R)-4-hydroxy-2-cyclopentenyl acetate 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 879098-70-1 (Z)-7-{(1R,2S,5S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid 
• 879098-90-5 thiocarbonic acid O-{4-[4-(1-benzyloxy-hexyl)-phenyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl} ester O-phenyl ester 

Relevant articles and documents

THERAPEUTIC COMPOUNDS

Compounds having a structure are disclosed herein. Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.

Cobalt(diamine)-catalyzed cross-coupling reaction of alkyl halides with arylmagnesium reagents: Stereoselective constructions of arylated asymmetric carbons and application to total synthesis of AH13205

A cobalt-diamine complex catalyzes the cross-coupling reactions of primary and secondary alkyl halides with aryl Grignard reagents. It is confirmed that oxidative addition of alkyl halide to cobalt proceeds via a radical process. Optically pure Ueno-Stork halo acetals undergo diastereoselective cross-coupling reactions, the products of which are transformed into optically active THF derivatives. A sequential radical cyclization/arylation reaction under cobalt catalysis provides extremely short access to a synthetic prostaglandin AH13205.

New reagent system for attaining high regio- and stereoselectivities in allylic displacement of 4-cyclopentene-1,3-diol monoacetate with aryl- and alkenylmagnesium bromides

(Chemical Equation Presented) Low regioselectivity of RMgBr (R = aryl, alkenyl) in the CuCN-catalyzed reaction with 4-cyclopentene-1,3-diol monoacetate is improved by addition of LiCl or MgCl2 to a similar extent as previously obtained with RMg