14844-73-6 Usage
Description
2,3-Dimethyl-1H-indole-5-carboxylic acid, also known as 5-Carboxy-2,3-dimethyl-1H-indole and 3AI-0532, is a chemical compound that falls under the category of indole carboxylic acids. This organic compound is characterized by its crystalline solid form, which is typically white or slightly yellow in color. With a molecular formula of C11H11NO2 and a molecular weight of 189.21 g/mol, it is a valuable compound in the field of synthetic chemistry due to its unique structural features. Proper handling and storage are crucial to ensure its safety and stability.
Uses
Used in Research and Development Laboratories:
2,3-Dimethyl-1H-indole-5-carboxylic acid is used as a research compound for its structural features in the field of synthetic chemistry. It aids in the development of new chemical entities and the study of chemical reactions and interactions.
Used in Synthetic Chemistry:
In the field of synthetic chemistry, 2,3-Dimethyl-1H-indole-5-carboxylic acid is used as a building block or intermediate in the synthesis of more complex molecules. Its unique structure allows for the creation of a wide range of chemical compounds, making it a valuable asset in the development of new materials and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 14844-73-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,8,4 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 14844-73:
(7*1)+(6*4)+(5*8)+(4*4)+(3*4)+(2*7)+(1*3)=116
116 % 10 = 6
So 14844-73-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H11NO2/c1-6-7(2)12-10-4-3-8(11(13)14)5-9(6)10/h3-5,12H,1-2H3,(H,13,14)/p-1
14844-73-6Relevant articles and documents
INDOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
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Paragraph 00179, (2021/09/04)
Methods of treating polyQ diseases or disorders such as Huntington's Disease are presented. Compounds of formula (I) of the disclosure are capable of binding directly to the polyQ segment of mutated huntingtin. This binding results in at least partial rev
Discovery of carbazole carboxamides as novel RORγt inverse agonists
Huang, Yafei,Yu, Mingcheng,Sun, Nannan,Tang, Ting,Yu, Fazhi,Song, Xiaoxia,Xie, Qiong,Fu, Wei,Shao, Liming,Wang, Yonghui
, p. 465 - 476 (2018/02/28)
A novel series of carbazole carboxamides was discovered as potent RORγt inverse agonists using a scaffold hybridization strategy. Structure-activity relationship exploration on the amide linker, carbazole ring and arylsulfone moiety of the hybrid amide 3a led to identification of potent RORγt inverse agonists. Compound 6c was found to have a good RORγt activity with an IC50 of 58.5 nM in FRET assay, and reasonable inhibitory activity in mouse Th17 cell differentiation assay (58.8% inhibition at 0.3 μM). The binding mode of carbazole carboxamides in RORγt ligand binding domain was discussed.
PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS
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Page/Page column 127, (2015/11/09)
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.