148459-54-5

Basic information

• Product Name: (4-AMINO-3-METHOXYPHENYL)METHANOL
• Synonyms: (4-AMINO-3-METHOXYPHENYL)METHANOL;[4-Amino-3-(methyloxy)phenyl]methanol;BenzeneMethanol,4-aMino-3-Methoxy-;4-Amino-3-methoxy-benzenemethanol
• CAS NO: 148459-54-5
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.18
• Mol File: 148459-54-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 312℃
• Flash Point: 142℃
• Appearance: /
• Density: 1.182
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (4-AMINO-3-METHOXYPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINO-3-METHOXYPHENYL)METHANOL(148459-54-5)
• EPA Substance Registry System: (4-AMINO-3-METHOXYPHENYL)METHANOL(148459-54-5)

Safety Data

• Hazardous Substances Data: 148459-54-5(Hazardous Substances Data)

Usage

Uses

(4-Amino-3-methoxyphenyl)methanol is a key intermediate in cyclotriveratrylene chemistry.

Upstream product

• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 80866-88-2 (3-methoxy-4-nitrophenyl)methanol 

Downstream Products

• 90151-40-9 4-amino-3-methoxybenzaldehyde 
• 1391419-32-1 2-(2,6-dichlorobenzyl)-4-(4-(hydroxymethyl)-2-methoxyphenylamino)-1,6-naphthyridin-5(6H)-one 
• 1391419-35-4 4-(2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-ylamino)-3-methoxybenzoic acid 
• 1391418-86-2 4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide 
• 1391419-30-9 2-chloro-4-(4-(hydroxymethyl)-2-methoxyphenylamino)-1,6-naphthyridin-5(6H)-one 
• 177478-52-3 4-acetamido-3-methoxybenzyl alcohol 
• 457059-31-3 (S)-2-[4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl]-2-(cyclopropylmethyl)acetic acid 
• 306769-05-1 4-[3-(2-methylphenyl)ureido]-3-methoxybenzyl chloride 
• 148459-56-7 4-chloroacetamido-3-methoxybenzyl chloroacetate 
• 148459-55-6 4-acetamido-3-methoxybenzyl acetate 

Relevant articles and documents

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents

A series of curcumin analogues with different substituents at the 4-position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines. Several novel curcumin analogues, especially 32 and 34, exhibited selective and potent cytotoxic activity against human epidermoid carcinoma cell line A-431 and human glioblastoma cell line U-251, implying their specific potential in the chemoprevention and chemotherapy of skin cancer and glioma. The preliminary SAR information extracted from the results suggested that introduction of appropriate substituents to the 4′-positions could be a promising approach for the development of new cytotoxic curcumin analogues with special selectivity for A-431 and U-251 cell lines.

Trifluoromethyl-substituted hydantoins, versatile building blocks for rational drug design

Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained pept