90151-40-9

Usage

Uses

Used in Pharmaceutical Research and Development:
Benzaldehyde, 4-amino-3-methoxy(9CI), is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Organic Chemistry:
In the field of organic chemistry, Benzaldehyde, 4-amino-3-methoxy(9CI), is used as a building block for the creation of complex organic molecules. Its versatile functional groups enable it to participate in a wide range of chemical reactions, facilitating the synthesis of novel organic compounds with potential applications in various industries.
Used in Material Science:
Benzaldehyde, 4-amino-3-methoxy(9CI), can be utilized in material science as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced characteristics, such as improved stability, reactivity, or selectivity.
Used in Analytical Chemistry:
As an analytical reagent, Benzaldehyde, 4-amino-3-methoxy(9CI), can be employed in various analytical techniques to detect or quantify specific compounds. Its unique chemical properties make it a valuable tool in the identification and quantification of target substances in complex samples.
Used in Flavor and Fragrance Industry:
Benzaldehyde, 4-amino-3-methoxy(9CI), can be used as a flavoring agent or a fragrance ingredient in the food, beverage, and cosmetics industries. Its distinct aroma and taste profile can contribute to the development of unique and appealing sensory experiences in various products.

InChI:InChI=1/C8H9NO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,9H2,1H3

Upstream product

• 61066-33-9 pyrimidine-2,4,5,6(1H,3H)-tetraone 
• 90-04-0 2-methoxy-phenylamine 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 50-00-0 formaldehyd 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 704-13-2 5-formyl-2-nitrophenol 
• 148459-54-5 (4-amino-3-methoxyphenyl)methanol 
• 41608-64-4 methyl 3-methoxy-4-aminobenzoate 
• 2486-69-3 3-methoxy-4-aminobenzoic acid 
• 80410-57-7 3-methoxy-4-nitrobenzaldehyde 

Downstream Products

• 1030-22-4 1,2-bis(4-cyanophenyl)diazene oxide 
• 1177015-72-3 1-bromo-2-methoxy-4-((E)-2-nitro-vinyl)-benzene 
• 113081-51-9 2-(4-bromo-3-methoxy-phenyl)-ethylamine 
• 1428796-73-9 N-(4-bromo-3-methoxyphenethyl)acetamide 
• 1428796-74-0 7-bromo-6-methoxy-1-methyl-3,4-dihydroisoquinoline 
• 1428796-75-1 ethyl 9-bromo-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-76-2 ethyl 8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-77-3 8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylic acid 
• 1428796-78-4 (R)-N-(1-(tert-butyldimethylsilyloxy)-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide 
• 1428796-07-9 (R)-3-(3-fluorophenyl)-N-(1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)-8-methoxy-9-(pyridin-3-yl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxamide 
• 1428796-79-5 ethyl 8-methoxy-9-vinyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-80-8 ethyl 9-ethyl-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-81-9 ethyl 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylate 
• 1428796-82-0 9-ethyl-3-(3-fluorophenyl)-8-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-2-carboxylic acid 

Relevant academic research and scientific papers

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that inhibit or modulate the activity of Chk-1 kinase. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds.

FSH RECEPTOR ANTAGONISTS

The invention relates to FSH receptor antagonist according to general formula (I) or a pharmaceutically acceptable salt thereof and to a pharmaceutical composition containing the same. The compounds can be used for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, and for the treatment of uterine fibroids and other menstrual-related disorders

Synthesis and preliminary evaluation of curcumin analogues as cytotoxic agents

A series of curcumin analogues with different substituents at the 4-position of the phenyl group were synthesized and screened for in vitro cytotoxicity against a panel of human cancer cell lines. Several novel curcumin analogues, especially 32 and 34, exhibited selective and potent cytotoxic activity against human epidermoid carcinoma cell line A-431 and human glioblastoma cell line U-251, implying their specific potential in the chemoprevention and chemotherapy of skin cancer and glioma. The preliminary SAR information extracted from the results suggested that introduction of appropriate substituents to the 4′-positions could be a promising approach for the development of new cytotoxic curcumin analogues with special selectivity for A-431 and U-251 cell lines.

(DIHYDRO) IMIDAZOISO (5, 1-A) QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS

The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula (1) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

(DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES

The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

(DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES

The invention relates to 5,6 - dihydropyrrolo [2,1-a] isoquinoline and pyrrolo[2,1-a] isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Based on the X-ray crystallography of our lead compound 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea in the checkpoint kinase 1 (Chk1) enzyme, we modified R4, and to a lesser extent, R2, and R5 of the phenyl ring, and made a variety of N-aryl-N′-pyrazinylurea Chk1 inhibitors. Enzymatic activity less than 20 nM was observed in 15 of 41 compounds. Compound 8i provided the best overall results in the cellular assays as it abrogated doxorubicin-induced cell cycle arrest (IC50 = 1.7 μM) and enhanced doxorubicin cytotoxicity (IC50 = 0.44 μM) while displaying no single agent activity.