148472-83-7Relevant academic research and scientific papers
Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: Synthesis and SAR studies
Silvestri, Romano,De Martino, Gabriella,La Regina, Giuseppe,Artico, Marino,Massa, Silvio,Vargiu, Laura,Mura, Massimo,Loi, Anna Giulia,Marceddu, Tiziana,La Colla, Paolo
, p. 2482 - 2493 (2007/10/03)
The potent anti-HIV-1 activities of L-737,126 (2) and PAS sulfones prompted us to design and test against HIV-1 in acutely infected MT-4 cells a number of novel 1- and 3-benzenesulfonylindoles. Indoles belonging to the 1-benzenesulfonyl series were found
Inhibitors of HIV reverse transcriptase
-
, (2008/06/13)
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
