148493-34-9

Basic information

• Product Name: 2,6-DICHLOROPYRIDINE-3-BORONIC ACID
• Synonyms: 2,6-Dichloropyridine-3-Boronic;2,6-Dichloropyridine-3-boronic acid(97%);3-Borono-2,6-dichloropyridine;2,6-Dichloropyridine-3-boronic Acid (contains varying amounts of Anhydride);2,6-DICHLOROPYRIDINE-3-BORONIC ACID;2,6-DICHLOROPYRIDIN-3-YLBORONIC ACID;2,6-DICHLORO-3-PYRIDYL BORONIC ACID;2,6-DICHLORO-3-PYRIDINEBORONIC ACID
• CAS NO: 148493-34-9
• Molecular Formula: C₅H₄BCl₂NO₂
• Molecular Weight: 191.81
• Product Categories: Pyridine;Boronic Acids & Esters;Pyridines;Organoborons;Boronic acid;Boronic Acids & Esters;Boronate Ester;Potassium Trifluoroborate
• Mol File: 148493-34-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 150°C(lit.)
• Boiling Point: 373.7 °C at 760 mmHg
• Flash Point: 179.8 °C
• Appearance: off-white solid
• Density: 1.56 g/cm³
• Vapor Pressure: 3E-06mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Keep Cold
• PKA: 6.40±0.58(Predicted)
• CAS DataBase Reference: 2,6-DICHLOROPYRIDINE-3-BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLOROPYRIDINE-3-BORONIC ACID(148493-34-9)
• EPA Substance Registry System: 2,6-DICHLOROPYRIDINE-3-BORONIC ACID(148493-34-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 148493-34-9(Hazardous Substances Data)

Usage

General Description

2,6-Dichloropyridine-3-boronic acid is a chemical compound with the molecular formula C5H4BCl2NO2. It is a boronic acid derivative and a pyridine compound, containing two chloro groups and a boronic acid functionality. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It serves as a key intermediate in the production of various biologically active molecules and can be utilized in the development of new drugs and functional materials. 2,6-Dichloropyridine-3-boronic acid plays a crucial role in organic synthesis due to its reactivity and versatility, making it an important compound in the field of chemical research and development.

InChI:InChI=1/C5H4BCl2NO2/c7-4-2-1-3(6(10)11)5(8)9-4/h1-2,10-11H

Upstream product

• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 26869-12-5 2-chloro-9H-pyrido[2,3-b]indole 
• 52764-11-1 2,6-dichloro-3-hydroxypyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 64677-58-3 2-phenyl-9H-pyrido[2,3-b]indole 
• 1427032-96-9 5-(12-cyano-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1427034-65-8 5-(12-bromo-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1427032-94-7 5-(12-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1427032-91-4 5-(12-chloro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 1426960-32-8 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide 
• 1214340-74-5 2,6-dichloro-3-methoxypyridine 
• 148493-40-7 N-[2-(2,6-dichloro-3-pyridinyl)phenyl]acetamide 

Relevant articles and documents

BICYCLIC ACYLGUANIDINE DERIVATIVE

An object of the present invention is to provide a novel and excellent agent for treating or preventing dementia, schizophrenia, and the like, based on the serotonin 5-HT5A receptor modulating action. It was confirmed that a bicyclic acylguanidine derivative which has a characteristic structure that guanidine is bonded to one ring of a bicyclic structure such as chromene and dihydronaphthalene through a carbonyl group and a cyclic group is bonded on the other ring, has a potent 5-HT5A receptor modulating action and an excellent pharmacological action based on this mechanism. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder.

Efficient synthesis of halohydroxypyridines by hydroxydeboronation

This paper describes a general method for the synthesis of halohydroxypyridines from novel halopyridinylboronic acids and esters recently described by some of us. Halopyridinylboronic acids and esters have been efficiently hydroxydeboronated under mild conditions by employing hydrogen peroxide or meta-chloroperbenzoic acid. These hydroxylations take place regioselectively without other oxidation (N-oxide formation).