1485124-89-7Relevant academic research and scientific papers
The synthesis of S-substituted derivatives of 3-[2-[(4-methylphenyl)amino] ethyl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazole-5-thiones and their antioxidative activity
Tumosiene, Ingrida,Jonuskiene, Ilona,Kantminiene, Kristina,Beresnevicius, Zigmuntas Jonas
, p. 319 - 327 (2014/03/21)
A series of novel S-substituted derivatives of 3-[2-[(4-methylphenyl)amino] ethyl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazole-5-thiones was synthesized by the reaction of 1,2,4-triazole-5-thiones with alkyl, benzyl, and phenacyl halides as well as halogen-containing esters or amides. The reactions were carried out in DMF in the presence of KOH, K2CO3, or triethylamine, or in dioxane in the presence of NaH. The synthesized compounds were screened for their free radical scavenging activity. N-[2-[5-(Butylsulfanyl)-4-phenyl-4H-1,2, 4-triazol-3-yl]ethyl]-4-methylaniline showed excellent antioxidant activity, 2.5 times higher than that of the antibiotic control (cefazolin). Graphical abstract: [Figure not available: see fulltext.]
