148519-91-9

Usage

Uses

Used in Pharmaceutical Industry:
[1,1-Biphenyl]-2,3-diol, 2-amino(9CI) is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. Its potential biological activities make it a valuable intermediate for the development of new drugs and therapeutic agents.
Used in Chemical Industry:
In the chemical industry, [1,1-Biphenyl]-2,3-diol, 2-amino(9CI) is utilized as an intermediate for the production of dyes and other fine chemicals. Its distinctive structure allows for the creation of a wide range of organic compounds, contributing to the diversity of products in the chemical market.
Used in Research and Development:
[1,1-Biphenyl]-2,3-diol, 2-amino(9CI) is also used in research and development efforts, particularly in the exploration of its potential biological activities. [1,1-Biphenyl]-2,3-diol, 2-amino(9CI)'s unique properties make it an interesting subject for further study, with the aim of discovering new applications and enhancing its utility in various industries.

Upstream product

• 86-74-8 9H-carbazole 

Relevant academic research and scientific papers

Alteration of the substrate specificity of the angular dioxygenase carbazole 1,9a-dioxygenase

Carbazole 1,9a-dioxygenase (CARDO) consists of terminal oxygenase (CARDO-O) and electron transport components. CARDO can catalyze specific oxygenation for various substrates: angular dioxygenation for carbazole and dibenzo-p-dioxin, lateral dioxygenation for anthracene, and monooxygenation for methylene carbon of fluorene and sulfide sulfur of dibenzothiophene. To elucidate the molecular mechanism determining its unique substrate specificity, 17 CARDO-O site-directed mutants at amino acid residues I262, F275, Q282, and F329, which form the substrate-interacting wall around the iron active site by CARDO-O crystal structure, were generated and characterized. F329 replacement dramatically reduced oxygenation activity. However, several mutants produced different products from the wild-type enzyme to a large extent: I262V and Q282Y (1-hydroxycarbazole), F275W (4-hydroxyfluorene), F275A (unidentified cis-dihydrodiol of fluoranthene), and I262A and I262W (monohydroxydibenzothiophenes). These results suggest the possibility that the respective substrates bind to the active sites of CARDO-O mutants in a different orientation from that of the wild-type enzyme.