148522-79-6

Basic information

• Product Name: C₂₅H₃₈N₂O₆Si
• Synonyms: C₂₅H₃₈N₂O₆Si
• CAS NO: 148522-79-6
• Molecular Weight: 490.672
• Mol File: 148522-79-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₈N₂O₆Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₈N₂O₆Si(148522-79-6)
• EPA Substance Registry System: C₂₅H₃₈N₂O₆Si(148522-79-6)

Safety Data

• Hazardous Substances Data: 148522-79-6(Hazardous Substances Data)

Upstream product

• 1610517-69-5 C₂₅H₃₆N₂O₅Si 
• 142325-10-8 5′-deoxy-5′-C-methenyl-3′-O-(tert-butyldimethylsilyl)thymidine 
• 131118-61-1 3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 50-89-5 thymidine 

Downstream Products

• 1610517-71-9 C₃₂H₃₃N₅O₆ 
• 130481-61-7 1-(3'-azido-2',3',5'-trideoxy-β-D-allofuranosyl)thymine 
• 189194-84-1 5'-deoxy-5'-C-(4,4'-dimethoxytrityloxymethyl)thymidine 

Relevant articles and documents

Phospho-carboxylic anhydride of a homologated nucleoside leads to primer degradation in the presence of a polymerase

Starting from thymidine, through a series of key synthetic transformations (e.g., Wittig reaction, hydroboration, Mitsunobu reaction and TEMPO oxidation) a nucleoside homologue bearing a phospho-carboxylic anhydride group at 6′ position was synthesized. The potential of polymerases to catalyze amide bond formation was investigated by using a modified primer with an amino group at 3′ position and the synthesized phosphoanhydro compound as substrate. Unfortunately, we did not observe the desired product either by gel electrophoresis or mass spectrometry. In contrast, the instability of the phosphoanhydro compound could lead to pyrophosphate formation and thus, to pyrophosphorolysis of the primer rather than to primer extension.