148547-50-6

Basic information

• Product Name: Piperazine, 1-(2-methoxy-5-nitrophenyl)-4-methyl-
• CAS NO: 148547-50-6
• Molecular Formula: C12H17N3O3
• Molecular Weight: 251.285
• Mol File: 148547-50-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(2-methoxy-5-nitrophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(2-methoxy-5-nitrophenyl)-4-methyl-(148547-50-6)
• EPA Substance Registry System: Piperazine, 1-(2-methoxy-5-nitrophenyl)-4-methyl-(148547-50-6)

Safety Data

• Hazardous Substances Data: 148547-50-6(Hazardous Substances Data)

Upstream product

• 148547-51-7 N-methyl-N'-(2-methoxyphenyl)-piperazine 
• 109-01-3 1-methyl-piperazine 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 1325188-71-3 1-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)pyrrolidin-2-one 
• 1325190-12-2 C₁₆H₂₃N₃O₄ 
• 1325188-73-5 1-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)pyrrolidine-2,5-dione 
• 148546-79-6 4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzamide 
• 148546-78-5 4-methoxy-3-(4-methyl-1-piperazinyl)benzeneamine 

Relevant articles and documents

5-HT RECEPTOR MODULATORS

The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.

Synthesis of potent and selective serotonin 5-HT1B receptor ligands

A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor a