148547-51-7

Basic information

• Product Name: Piperazine, 1-(2-methoxyphenyl)-4-methyl-
• CAS NO: 148547-51-7
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• Mol File: 148547-51-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(2-methoxyphenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(2-methoxyphenyl)-4-methyl-(148547-51-7)
• EPA Substance Registry System: Piperazine, 1-(2-methoxyphenyl)-4-methyl-(148547-51-7)

Safety Data

• Hazardous Substances Data: 148547-51-7(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 766-51-8 2-Chloroanisole 
• 768289-44-7 1-formyl-4-(2-methoxyphenyl)piperazine 
• 50-00-0 formaldehyd 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 380639-26-9 1-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1H-1,2,3-benzotriazole 
• 91-16-7 1,2-dimethoxybenzene 
• 110-85-0 piperazine 

Downstream Products

• 148547-50-6 1-(2-Methoxy-5-nitro-phenyl)-4-methyl-piperazine 
• 960402-38-4 1-(4-bromo-2-methoxyphenyl)-4-methylpiperazine 
• 1620294-68-9 tert-butyl ((5-((2-(4-methylpiperazin-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate 
• 1620294-66-7 1-(2-(allyloxy)phenyl)-4-methylpiperazine 
• 189762-98-9 2-(4-methylpiperazin-1-yl)phenol 
• 1325188-73-5 1-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)pyrrolidine-2,5-dione 
• 1325190-12-2 C₁₆H₂₃N₃O₄ 
• 148546-79-6 4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzamide 
• 148546-78-5 4-methoxy-3-(4-methyl-1-piperazinyl)benzeneamine 

Relevant articles and documents

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

Chelating Bis(1,2,3-triazol-5-ylidene) Rhodium Complexes: Versatile Catalysts for Hydrosilylation Reactions

NHC-rhodium complexes (NHC=N-heterocyclic carbenes) have been widely used as efficient catalysts for hydrosilylation reactions. However, the substrates were mostly limited to reactive carbonyl compounds (aldehydes and ketones) or carbon-carbon multiple bonds. Here, we describe the application of newly-developed chelating bis(tzNHC)-rhodium complexes (tz=1,2,3-triazol-5-ylidene) for several reductive transformations. With these catalysts, the formal reductive methylation of amines using carbon dioxide, the hydrosilylation of amides and carboxylic acids, and the reductive alkylation of amines using carboxylic acids have been achieved under mild reaction conditions.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor

The dopamine D3 receptor (D3R) has been implicated in substance abuse and other neuropsychiatric disorders. The high sequence homology between the D3R and D2R, especially within the orthosteric binding site (OBS) that binds dopamine, has made the developm