148563-16-0

Basic information

• Product Name: R-ALBUTEROL HYDROCHLORIDE
• Synonyms: R-ALBUTEROL HYDROCHLORIDE;1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (a1R)-, sulfate (2:1) (salt) (9CI);Levalbuterol sulfate
• CAS NO: 148563-16-0
• Molecular Formula: 2C₁₃H₂₁NO₃*H₂O₄S
• Molecular Weight: 275.77168
• Mol File: 148563-16-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 433.5 °C at 760 mmHg
• Flash Point: 159.5 °C
• Appearance: /
• Density: 1.152 g/cm³
• Storage Temp.: -20°C Freezer
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: R-ALBUTEROL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: R-ALBUTEROL HYDROCHLORIDE(148563-16-0)
• EPA Substance Registry System: R-ALBUTEROL HYDROCHLORIDE(148563-16-0)

Safety Data

• Hazardous Substances Data: 148563-16-0(Hazardous Substances Data)

Usage

Uses

Bronchodilator; asthma prophylactic.

InChI:InChI=1/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)/t12-;/m0./s1

Downstream Products

• 324000-05-7 (R)-2-tert-butylamino-1-(4-hydroxy-2-hydroxymethyl-phenyl)ethanol 
• 324000-05-7 (S)-2-tert-butylamino-1-(4-hydroxy-2-hydroxymethyl-phenyl)ethanol 
• 4199-09-1 (S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol 
• 525-66-6 (R)-propranolol 

Relevant articles and documents

Process for the enantiomeric enrichment of salbutamol and salbutamol precursors

The present invention relates to a process for the enantiomeric enrichment of salbutamol and salbutamol precursors and the acid-addition salts thereof: where R is hydrogen or benzyl, R' is hydrogen or benzyl and X is CH2OH or COO-C1-C4-alkyl the process comprising the crystallization of a compound of the formula I in the form of its acid-addition salt with an achiral carboxylic acid A that has at least three carbon atoms and a solubility of less than 50 g/l in water at pH 3, 20°C and 1013 mbar, from a solution containing a mixture of the enantiomers of the compound of formula I and the achiral carboxylic acid A in the presence of seed crystals of the desired enantiomer of the compound of formula I or the acid addition salt thereof, whereby the enantiomerically enriched acid-addition salt of the compound of formula I is obtained.