324000-05-7

Basic information

• Product Name: (+)-Albuterol sulfate (1:1)
• Synonyms: 1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (a1S)-, sulfate (1:1) (salt) (9CI)
• CAS NO: 324000-05-7
• Molecular Formula: MW:
• Molecular Weight: 337.39
• Mol File: 324000-05-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+)-Albuterol sulfate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-Albuterol sulfate (1:1)(324000-05-7)
• EPA Substance Registry System: (+)-Albuterol sulfate (1:1)(324000-05-7)

Safety Data

• Hazardous Substances Data: 324000-05-7(Hazardous Substances Data)

Upstream product

• 7664-93-9 sulfuric acid 
• 18559-94-9 Salbutamol 
• 324000-05-7 2-tert-butylamino-1-(4-hydroxy-2-hydroxymethyl-phenyl)ethanol 
• 34245-12-0 salbutamol sulfate 
• 525-66-6 propranolol 
• 27475-09-8 5-acetyl-2-benzyloxybenzoic acid methyl ester 
• 174607-70-6 methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(benzyloxy) benzoate 
• 56796-66-8 α¹-[[(1,1-dimethylethyl)amino]methyl]-4-(benzyloxy)-1,3-benzenedimethanol 
• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 
• 90-01-7 salicylic alcohol 
• 75-64-9 tert-butylamine 
• 69-72-7 salicylic acid 
• 174607-68-2 (R)-1-[4-benzyloxy-3-hydroxymethylphenyl]-2-tert-butylaminoethanol 

Downstream Products

• 324000-05-7 (R)-2-tert-butylamino-1-(4-hydroxy-2-hydroxymethyl-phenyl)ethanol 
• 324000-05-7 (S)-2-tert-butylamino-1-(4-hydroxy-2-hydroxymethyl-phenyl)ethanol 
• 4199-09-1 (S)-1-isopropylamino-3-(1-naphthyloxy)-2-propanol 
• 525-66-6 (R)-propranolol 

Relevant articles and documents

Preparation method of salbutamol sulfate

The invention provides a preparation method of salbutamol sulfate, and relates to the technical field of chemical synthesis. The preparation method of salbutamol sulfate comprises the following steps: (a) carrying out reaction on salicylic acid and a tert-butyl amino acetyl halogenating reagent under the action of a chlorinating agent to generate an intermediate 1; (b) reacting the intermediate 1 under the action of Lewis acid to generate an intermediate 2; (c) reacting the intermediate 2 under the action of an acid reagent to generate an intermediate 3; (d) reacting the intermediate 3 with a reducing agent under the action of a catalyst to generate salbutamol; and (e) reacting salbutamol with sulfuric acid to generate salbutamol sulfate. The raw materials are simple and easy to obtain, the reaction condition is mild, the reaction operation is simple, the reaction process is easier to control, and the safety coefficient is high; used raw materials, solvents and the like are environment-friendly; and the yield and purity of salbutamol sulfate are high, and a process route capable of industrially producing a product with higher quality is provided.

Preparation method of salbutamol sulfate

The invention discloses a preparation method of salbutamol sulfate, and relates to a compound shown as a formula V. The related reaction type is simple, the used raw materials are cheap and easy to obtain, the yield is high, the environmental protection pressure is small, and the method is suitable for industrial production.

PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

A process for the preparation of optically pure R (?) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 /sub