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148583-65-7

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148583-65-7 Usage

General Description

4-fluoro-2-isopropoxyaniline is a chemical compound with the molecular formula C9H12FNO. It is an aromatic amine derivative that contains a fluoro substituent and an isopropoxy group. 4-fluoro-2-isopropoxyaniline is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It also has potential applications in the field of organic synthesis and material science. 4-fluoro-2-isopropoxyaniline is considered to be a hazardous chemical and appropriate safety measures should be taken when handling it.

Check Digit Verification of cas no

The CAS Registry Mumber 148583-65-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,5,8 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 148583-65:
(8*1)+(7*4)+(6*8)+(5*5)+(4*8)+(3*3)+(2*6)+(1*5)=167
167 % 10 = 7
So 148583-65-7 is a valid CAS Registry Number.

148583-65-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-fluoro-2-propan-2-yloxyaniline

1.2 Other means of identification

Product number -
Other names 4-fluoro-2-isopropoxyaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148583-65-7 SDS

148583-65-7Relevant articles and documents

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Teo, Theodosia,Yang, Yuchao,Yu, Mingfeng,Basnet, Sunita K.C.,Gillam, Todd,Hou, Jinqiang,Schmid, Raffaella M.,Kumarasiri, Malika,Diab, Sarah,Albrecht, Hugo,Sykes, Matthew J.,Wang, Shudong

, p. 539 - 550 (2015/10/12)

Deregulation of protein synthesis is a common event in cancer. As MAPK-interacting kinases (Mnks) play critical roles in regulation of protein synthesis, they have emerged as novel anti-cancer targets. Mnks phosphorylate eukaryotic initiation factor 4E (eIF4E) and promote eIF4E-mediated oncogenic activity. Given that the kinase activity of Mnks is essential for oncogenesis but is dispensable for normal development, the discovery of potent and selective pharmacological Mnk inhibitors provides pharmacological target validation and offers a new strategy for cancer treatment. Herein, comprehensive in silico screening approaches were deployed, and three thieno[2,3-d]pyrimidine and pyrazolo[3,4-d]pyrimidine derivatives were identified as hit compounds. Further chemical modification of thieno[2,3-d]pyrimidine derivative 3 has given rise to a series of highly potent Mnk2 inhibitors that could be potential leads for the treatment of acute myeloid leukemia.

Piperazine compounds and medicinal use thereof

-

, (2008/06/13)

The present invention relates to a piperazine compound of the formula wherein R1and R2are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4and R5are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6and R7are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8and R9are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.

4-ARYLPIPERAZINES AND 4-ARYLPIPERIDINES

-

, (2008/06/13)

Compounds of the general formula I: STR1 are disclosed as novel antipsychotic agents.

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