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(S)-tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is a chemical compound belonging to the class of morpholine derivatives. It is a tosylate ester, characterized by the presence of a tosylate group (tosyloxy) attached to the molecule. (S)-tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is known for its stability and steric hindrance provided by the tert-butyl group, making it a valuable building block in organic chemistry. The tosylate group's ability to participate in various substitution reactions adds to its versatility and value in synthetic chemistry.

148638-76-0

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148638-76-0 Usage

Uses

Used in Organic Synthesis:
(S)-tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is used as a versatile intermediate for the synthesis of various bioactive compounds. Its unique structure and functional groups allow for a wide range of reactions, making it a valuable asset in the development of new organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (S)-tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is used as a potential precursor for the synthesis of pharmaceutical agents. Its stability and reactivity make it an attractive candidate for the development of new drugs with potential therapeutic applications.
Used in Chemical Reactions:
(S)-tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is used as a reagent in various chemical reactions due to its tosylate group's ability to participate in substitution reactions. This property makes it a valuable tool for chemists in the synthesis of complex molecules and the development of novel chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 148638-76-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,6,3 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 148638-76:
(8*1)+(7*4)+(6*8)+(5*6)+(4*3)+(3*8)+(2*7)+(1*6)=170
170 % 10 = 0
So 148638-76-0 is a valid CAS Registry Number.

148638-76-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-tert-butoxycarbonyl-2-p-toluenesulfonyloxymethylmorpholine

1.2 Other means of identification

Product number -
Other names (S)-tert-butyl 2-((tosyloxy)methyl)morpholine-4-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148638-76-0 SDS

148638-76-0Relevant articles and documents

COMPOUNDS USEFUL FOR INHIBITING CDK7

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Page/Page column 48, (2021/12/08)

CDK7 inhibitors according to the formula (I): wherein X is -CH(OH)CH3, -CHFCH3, -CF2CH3, or -CF3; Y is -CH=CH2 or C2H=C2H2; and Z is CH(CH3)

NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS

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Page/Page column 93, (2019/05/15)

The present invention covers substituted Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Solid dispersions containing an apoptosis-inducing agent

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Page/Page column 182-183, (2019/03/15)

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

NOVEL OXOQUINOLIZINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION

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Page/Page column 61, (2019/12/25)

The present invention relates to novel compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as described herein, and their pharmaceutically 5 acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Novel Triazolopyrazine Derivatives and Use Thereof

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Paragraph 0119; 0126, (2017/07/31)

The present invention relates to novel triazolopyrazine derivatives or a pharmaceutically acceptable salt, and a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating hyperproliferative disorders, containing the same as active ingredients. The present invention effectively inhibits c-Met tyrosine kinase activity, thereby being able to be useful as a drug for various hyperproliferative disorders such as cancers, psoriasis, rheumatoid arthritis, diabetic retinitis, etc. related to excessive cell proliferation and growth by abnormal kinase activation.

1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES

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Page/Page column 288; 289, (2016/07/05)

The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF

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Paragraph 0065; 0069; 0070, (2015/10/06)

The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

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Paragraph 0186, (2014/09/29)

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-(TRIFLUOROMETHYL)-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

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Page/Page column 43-44, (2013/12/03)

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5- (trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to her

BENZAMIDE DERIVATIVES, THEIR PREPARATION AND USES IN MEDICINE THEREOF

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Page/Page column 15, (2010/06/15)

The present invention discloses novel benzamide derivatives represented by general formula (I), their preparation, pharmaceutical compositions containing the derivatives and their use as medicament, especially as a 5-HT4 stimulator, wherein the

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