148638-76-0Relevant articles and documents
COMPOUNDS USEFUL FOR INHIBITING CDK7
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Page/Page column 48, (2021/12/08)
CDK7 inhibitors according to the formula (I): wherein X is -CH(OH)CH3, -CHFCH3, -CF2CH3, or -CF3; Y is -CH=CH2 or C2H=C2H2; and Z is CH(CH3)
Solid dispersions containing an apoptosis-inducing agent
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Page/Page column 182-183, (2019/03/15)
A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.
Novel Triazolopyrazine Derivatives and Use Thereof
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Paragraph 0119; 0126, (2017/07/31)
The present invention relates to novel triazolopyrazine derivatives or a pharmaceutically acceptable salt, and a pharmaceutical composition for inhibiting c-Met tyrosine kinase activity and a pharmaceutical composition for preventing or treating hyperproliferative disorders, containing the same as active ingredients. The present invention effectively inhibits c-Met tyrosine kinase activity, thereby being able to be useful as a drug for various hyperproliferative disorders such as cancers, psoriasis, rheumatoid arthritis, diabetic retinitis, etc. related to excessive cell proliferation and growth by abnormal kinase activation.