1486520-82-4Relevant academic research and scientific papers
Synthesis and cytotoxicity of novel thioxo-quinazolino[3,4-a]quinazolinones
Mohammadhosseini, Negar,Saeedi, Mina,Moradi, Shahram,Mahdavi, Mohammad,Firuzi, Omidreza,Foroumadi, Alireza,Shafiee, Abbas
, p. 125 - 134 (2017)
Various thioxo-quinazolino[3,4-a]quinazolinones were prepared and evaluated for their cytotoxicity in MOLT-4 (lymphoblastic leukemia) and MCF-7 (breast adenocarcinoma) cell lines. Synthesis of the target compounds was started from isatoic anhydride. Successive reaction of isatoic anhydride with benzylamine and 2-nitrobenzaldehyde, reduction of the nitro group, and reaction with CS2 gave 12-benzyl-6-thioxo-6,7,11b,12-tetrahydro-13H-quinazolino[3,4-a]quinazolin-13-one. The latter compound reacted with various 2-chloro-N-substituted acetamides to afford the corresponding fused quinazolinone derivatives.
An efficient four-step approach toward fused triazino[1,6-a] quinazolines
Sayahi, Mohammad Hosein,Baghersaei, Shirin,Goli, Fereshteh,Moghimi, Setareh,Mahdavi, Mohammad,Firoozpour, Loghman,Shafiee, Abbas,Foroumadi, Alireza
, p. 189 - 192 (2016/05/09)
Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6-a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.
Novel four-step synthesis of thioxo-quinazolino[3,4- A ]quinazolinone derivatives
Shafii, Behnaz,Saeedi, Mina,Mahdavi, Mohammad,Foroumadi, Alireza,Shafiee, Abbas
, p. 215 - 221 (2013/12/04)
A novel synthesis of thioxo-quinazolino[3,4-a]quinazolinone framework was developed through a four-step reaction starting from isatoic anhydride. The resulting 2-aminobenzamides from the reaction of isatoic anhydride and different amines underwent coupling-cyclization reaction with 2-nitrobenzaldehydes, reduction of nitro group, and then cyclization reaction with carbon disulfide (CS2). All steps were carried out under easy and user-friendly conditions in a short time without using expensive catalysts or reagents. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
