5471-20-5

Basic information

• Product Name: 2-AMINO-N-BENZYL-BENZAMIDE
• Synonyms: benzamide, 2-amino-N-(phenylmethyl)-;2-amino-N-(phenylmethyl)benzamide;2-azanyl-N-(phenylmethyl)benzamide
• CAS NO: 5471-20-5
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.28
• Mol File: 5471-20-5.mol
• Article Data: 92

Chemical Properties

• Boiling Point: 459.7 °C at 760 mmHg
• Flash Point: 231.8 °C
• Appearance: /
• Density: 1.173 g/cm³
• Vapor Pressure: 1.23E-08mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-AMINO-N-BENZYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-BENZYL-BENZAMIDE(5471-20-5)
• EPA Substance Registry System: 2-AMINO-N-BENZYL-BENZAMIDE(5471-20-5)

Safety Data

• Hazardous Substances Data: 5471-20-5(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-BENZYL-BENZAMIDE, also known as Benzyl-benzolamide, is a chemical compound with the molecular formula C14H14N2O. It is a white solid that is soluble in organic solvents. 2-AMINO-N-BENZYL-BENZAMIDE is primarily used as an intermediate in the synthesis of pharmaceuticals and various other organic compounds. It has potential applications in the field of medicine, particularly as a building block for the synthesis of biologically active molecules. 2-AMINO-N-BENZYL-BENZAMIDE may also have applications in research and development, as well as in the production of specialty chemicals.

InChI:InChI=1/C14H14N2O/c15-13-9-5-4-8-12(13)14(17)16-10-11-6-2-1-3-7-11/h1-9H,10,15H2,(H,16,17)

Upstream product

• 100-46-9 benzylamine 
• 60007-51-4 3-(2-oxo-2-phenylethyl)quinazolin-4(3H)-one 
• 703-65-1 3,1-benzothiazine-2,4-dione 
• 118-92-3 anthranilic acid 
• 72-18-4 L-valine 
• 73178-23-1 N-benzyl-2-iodobenzamide 
• 107-11-9 1-amino-2-propene 
• 91-56-5 indole-2,3-dione 
• 552-89-6 2-nitro-benzaldehyde 
• 271-58-9 anthranil 
• 5344-90-1 2-Aminobenzyl alcohol 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 117576-29-1 (2?aminophenyl)(1H?benzo[d][1,2,3]triazol?1?yl)methanone 

Downstream Products

• 14870-61-2 3-benzyl-2-naphthalen-1-yl-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one 
• 14870-60-1 3-benzyl-2,3-dihydro-2-phenylbenzo[d][1,3,2]diazaborinin-4(1H)-one 
• 1904-75-2 2-((benzylamino)methyl)aniline 
• 14135-48-9 3-benzyl-2-hydroxy-2,3-dihydro-1H-benzo[1,3,2]diazaborinin-4-one 
• 56043-06-2 3-benzyl-2-mercapto-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione; pyridine salt 
• 15561-72-5 3-benzylbenzo[d][1,2,3]triazin-4(3H)-one 
• 4260-34-8 3-benzyl-2-methyl-3H-quinazolin-4-one 
• 16285-33-9 2,3-dihydro-2-phenyl-3-(phenylmethyl)-4(1H)-quinazolinone 
• 1385789-96-7 1-acetyl-3'-benzyl-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione 
• 1416791-84-8 4-benzyl-1,2-dihydro-2,2-dimethyl-4H-benzo[e][1,4]diazepine-3,5-dione 
• 1416791-85-9 4-benzyl-2-ethyl-1,2-dihydro-2-methyl-4H-benzo[e][1,4]diazepine-3,5-dione 
• 5388-11-4 3-benzyl-3H-quinazolin-4-one 
• 23942-45-2 4-benzyl-2,3,3a,4-tetrahydro-3a-methylpyrrolo[1,2-a]quinazoline-1,5-dione 

Relevant articles and documents

Synthesis and anion recognition studies of new ureylbenzamide-based receptors

A new group of ureylbenzamide-based receptors (1–4) has been synthesized; its binding affinity and capacity to form supramolecular complexes in solution with different anions have been investigated. For designing these receptors, it was considered a combination of the positions of the urea and amide groups (ortho and meta), and the chromophore groups naphthyl and nitrophenyl, yielding four receptors. The position and chromophore structure affected the acidity of the urea and amide hydrogens in the order 4>3>2>1. All the spectroscopic studies showed a significant change of 1 and 2 compared with 3 and 4 in the presence of different TBAX salts in acetonitrile. The 1H-NMR spectra show a preferential interaction of the anions with the urea group in receptors 1 and 2 due to the less steric hindrance, while there is a cooperative interaction of amide group in receptors 3 and 4 due to the closeness of both groups.

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

An efficient and facile method has been developed for the synthesis of various 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino-N-(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method. Graphic abstract: [Figure not available: see fulltext.]