148680-22-2

Upstream product

• 67040-46-4 (5S)-5-[(1-ethoxyethyl)oxymethyl]tetrahydro-1H-2-pyrrolone 
• 15865-57-3 2-nitro-3-methoxybenzoyl chloride 
• 148680-21-1 Acetic acid (S)-1-(3-methoxy-2-nitro-benzoyl)-2,3-dihydro-1H-pyrrol-2-ylmethyl ester 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 148680-23-3 Acetic acid (S)-4-((E)-2-dimethylcarbamoyl-vinyl)-1-(3-methoxy-2-nitro-benzoyl)-2,3-dihydro-1H-pyrrol-2-ylmethyl ester 
• 148680-24-4 {2-[(S)-4-((E)-2-Dimethylcarbamoyl-vinyl)-2-hydroxymethyl-2,3-dihydro-pyrrole-1-carbonyl]-6-methoxy-phenyl}-carbamic acid allyl ester 
• 110652-73-8 Porothramycin A 
• 152032-91-2 (E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide 
• 152032-92-3 (E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide 
• 110652-72-7 Porothramycin B 

Relevant academic research and scientific papers

Enantioselective synthesis of (+)porothramycin B and its 9-demethoxy analogue

(+)9-Demethoxyporothramycin B 3a and (+) porothramycin B 3b were synthesized from (S) pyroglutamic acid through a versatile and efficient route.

Total synthesis of (+)-porothramycin B

The first total synthesis of (+)-porothramycin B (1b is described. Our synthetic pathway can be readily applied to the synthesis of other members of the pyrrolo[1,4]benzodiazepine antibiotics.