148704-76-1

Basic information

• Product Name: N-(8-quinolinyl)-1-pyrrolidinesulfonamide
• Synonyms: N-(8-quinolinyl)-1-pyrrolidinesulfonamide
• CAS NO: 148704-76-1
• Molecular Formula: C13H15N3O2S
• Molecular Weight: 277.3421
• Mol File: 148704-76-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(8-quinolinyl)-1-pyrrolidinesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(8-quinolinyl)-1-pyrrolidinesulfonamide(148704-76-1)
• EPA Substance Registry System: N-(8-quinolinyl)-1-pyrrolidinesulfonamide(148704-76-1)

Safety Data

• Hazardous Substances Data: 148704-76-1(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 578-66-5 8-amino quinoline 

Relevant articles and documents

Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies

Carbonic anhydrase (CA) IX, and XII isoforms are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for some cancers because it is overexpressed in hypoxic tumors and this overexpression leads to poor prognosis. Novel twenty-seven compounds in two series (sulfamoylcarbamate-based quinoline (2a-2o) and sulfamide-based quinoline (3a-3l)) were synthesized and characterized by means of IR, NMR, and mass spectra. Their inhibitory activities were evaluated against CA I, CA II, CA IX, and CA XII isoforms. 2-Phenylpropyl (N-(quinolin-8-yl)sulfamoyl)carbamate (2m) exhibited the highest hCA IX inhibition with the Ki of 0.5 μM. In addition, cytotoxic effects of the synthesized compounds on human colorectal adenocarcinoma (HT-29; HTB-38), human breast adenocarcinoma (MCF7; HTB-22), human prostate adenocarcinoma (PC3; CRL-1435) and human healthy skin fibroblast (CCD-986Sk; CRL-1947) cell lines were examined. The cytotoxicity results showed that 2j, 3a, 3e, 3f are most active compounds in all cell lines (HT-29, MCF7, PC3, and CCD-986Sk).