148715-44-0

Basic information

• Product Name: N-(2-chloroethyl)-4,5-diphenyl-4-oxazolin-2-one
• Synonyms: N-(2-chloroethyl)-4,5-diphenyl-4-oxazolin-2-one
• CAS NO: 148715-44-0
• Molecular Weight: 299.757
• Mol File: 148715-44-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-chloroethyl)-4,5-diphenyl-4-oxazolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloroethyl)-4,5-diphenyl-4-oxazolin-2-one(148715-44-0)
• EPA Substance Registry System: N-(2-chloroethyl)-4,5-diphenyl-4-oxazolin-2-one(148715-44-0)

Safety Data

• Hazardous Substances Data: 148715-44-0(Hazardous Substances Data)

Upstream product

• 21240-34-6 4,5-diphenyl-1,3-dioxol-2-one 
• 870-24-6 2-chloroethanamine hydrochloride 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 119-53-9 2-hydroxy-2-phenylacetophenone 

Downstream Products

• 148715-56-4 3-<(E)-<2-(1-tosyl-5-indolyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 148715-52-0 3-<(E)-<2-(2-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 148715-53-1 3-<(E)-<2-(4-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 148715-48-4 3-<(E)-<2-(2-fluorophenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 148715-49-5 3-<(E)-<2-(3-fluorophenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone 
• 148715-54-2 4-<2(E)-(4,5-diphenyl-2-oxo-4-oxazolin-3-yl)ethenyl>phenol 
• 148715-47-3 3-<(E)-(2-phenylethenyl)>-4,5-diphenyl-2(3H)oxazolone 
• 148715-46-2 3-ethenyl-4,5-diphenyl-2(3H)oxazolone 
• 148715-45-1 3-(2-iodoethyl)-4,5-diphenyl-2(3H)oxazolone 

Relevant articles and documents

Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives

Novel oxazolidin-2-one-linked 1,2,3-triazole derivatives (4a-k) were synthesized by straightforward and versatile azide-enolate (3 + 2) cycloaddition. The series of compounds was screened for antifungal activity against four filamentous fungi as well as six yeast species of Candida spp. According to their efficiency and breadth of scope, they can be ordered as 4k > 4d > 4h > 4a, especially in relation to the activity displayed against Candida glabrata ATCC-34138, Trichosporon cutaneum ATCC-28592 and Mucor hiemalis ATCC-8690, i.e. compounds 4d, 4h and 4k showed excellent activity against C. glabrata (MIC 0.12, 0.25 and 0.12 μg mL-1, respectively), better than that of itraconazole (MIC 1 μg ml-1). The activity of compound 4d (MIC = 2 μg mL-1) was higher than that observed for the standard antifungal drug (MIC = 8 μg mL-1) against Trichosporon cutaneum, while compound 4k displayed an excellent antimycotic activity against Mucor hiemalis (MIC = 2 μg mL-1vs. 4 μg mL-1 for itraconazole). In addition, we describe herein a novel mild and eco-friendly synthetic protocol for obtaining β-ketosulfones (adducts to afford compounds 4a-k) from α-brominated carbonyls in an aqueous nanomicellar medium at room temperature.

Phenethylamines via Heck Arylation of a New Vinylamine Equivalent

A new vinylamine equivalent, N-vinyloxazolone 3, has been prepared in three steps and shown to undergo Heck arylation with a variety of substrates.The Heck adducts thus obtained are then converted in one step and high yield to phenethylamine hydrochlorides.As a general synthetic method for preparation of substituted phenethylamines, use of this new reagent is shown to be superior to N-vinylphthalimide in number of steps, regiospecificity, and chemical yield.