148729-74-2

Upstream product

• 676-58-4 methylmagnesium chloride 
• 125335-96-8 2-(1-Benzenesulfonyl-5-methoxyindolyl)-4-(3-diethylaminocarbonyl-2-methoxypyridyl)ketone 
• 148729-72-0 2-(1-Benzenesulfonyl-5-methoxyindolyl)-4-(3-diethylaminocarbonyl-2-methoxypyridyl)methanol 

Downstream Products

• 125336-02-9 1-(2-(1-Benzenesulfonyl-5-methoxyindolyl))-1,3-dihydro-4-methoxy-1-methyl-3-oxofuro<3,4-c>pyridine 
• 125336-06-3 1-<2-(1-Benzenesulfonyl-5-methoxyindolyl)>-1,3-dihydro-3-hydroxy-4-methoxy-1-methylfuro<3,4-c>pyridine 
• 125336-09-6 1-<2-(1-Benzenesulfonyl-5-methoxyindolyl)>-1,3-dihydro-1,3-dimethyl-3-hydroxy-4-methoxyfuro<3,4-c>pyridine 

Relevant academic research and scientific papers

Industrial synthesis in mass production. Ellipticine. II. The elaboration of a new approach to GH-pyrido[4,3:b]carbazoles and analogs. B. The recovery of tetracyclic structures

Total synthesis of modified ellipticines 1c and 1f is described from 2-chloronicotinic acid and respectively 5-methoxy-indole and 5-azaindole in 11 to 13 steps with overall yields of 11% and 18%. With respect to the numerous synthesis described in the literature, the originality of this approach resides above all in the formation of ring C in basic medium, such conditions being dictated by the presence of the pyridine A ring in the case of 1f. Both synthesis have been extrapolated to produce several kilograms of final product. The second part deals with the elaboration of tetracyclic structures from precursors.