252947-01-6

Basic information

• Product Name: METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER
• Synonyms: 4,4,5,5,5-PENTAFLUOROPENTYL METHANESULFONATE;4,4,5,5,5-PENTAFLUOROPENTYLMETHANSULFONATE;METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER;4,4,5,5,5-Pentafluoropentylmethanesulphonate;4,4,5,5,5-PENTAFLUOROPENTYL METHANESULFONATE(WXG02862)
• CAS NO: 252947-01-6
• Molecular Formula: C₆H₉F₅O₃S
• Molecular Weight: 256.19
• Mol File: 252947-01-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 243.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.405±0.06 g/cm3(Predicted)
• CAS DataBase Reference: METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER(252947-01-6)
• EPA Substance Registry System: METHANESULFONIC ACID 4,4,5,5,5-PENTAFLUORO-PENTYL ESTER(252947-01-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 252947-01-6(Hazardous Substances Data)

Usage

General Description

Methanesulfonic acid 4,4,5,5,5-pentafluoro-pentyl ester is a chemical compound that is often used in the field of chemistry as a reagent. Its chemical formula is C7H11F5O3S. This acid ester is highly reactive, making it a useful tool in synthetic chemistry. The presence of five fluorine atoms lends significant stability to the chemical, helping to resist unwanted side reactions. It’s used in organic synthesis, where it is often a critical part of creating a larger, more complex compound. However, it is a potentially hazardous substance that should be handled with care, as it is corrosive and may cause severe burns and eye damage.

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 148043-73-6 4,4,5,5,5-pentafluorpentan-1-ol 

Downstream Products

• 151556-31-9 1,1,1,2,2-pentafluoro-5-iodo-pentane 
• 875573-69-6 17-O-acetyl-S-deoxo-fulvestrant 
• 153004-31-0 (+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol 

Relevant articles and documents

A new compound and its preparation method and elimination method (by machine translation)

The invention relates to medical and chemical field, provides a new compound, the compounds have the formula I structure, is preparing novel anti-breast cancer drug of fulvestrant in the process more difficult to avoid one of the impurity. The present invention provides a compound of formula I of the synthetic route, and to reduce or avoid the preparation of fluorine Uygursi Qun produced in the process of method, and in its generated after the method of removing it, not only reduces the growing into this impurity the waste of raw materials, also there to have ruled out the impurities to the rear edge of fulvestrant to purification of the product and the impact of the yield. (by machine translation)

Fulvestrant process for the preparation of intermediates

The invention provides a preparation method of a fulvestrant intermediate. The preparation method of the fulvestrant intermediate is characterized in that a water extraction starting material 1,9-nonanediol is adopted for controlling the content of 1,8-octylene glycol, an antioxidant is added for reducing byproducts which are generated by Michael addition and difficult to purify and pH value is regulated for reducing production of aromatized impurities difficult to remove, so that a route for preparing fulvestrant by virtue of the fulvestrant intermediate has the advantages that a final product is difficult to purify, the cost is low and industrialization can be easily realized. The prepared fulvestrant intermediate lays a key foundation for obtaining a route for synthesizing fulvestrant which is easy to purify and easy for industrialization.

PROCESS FOR PREPARING 7-ALPHA-[9-(4,4,5,5,5-PENTAFLUOROTHIOPENTYL) NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-BETA-DIOL

A process is described for the industrial scale preparation of 7a-[9-(4,4,5,5,5- 5 pentafluorothiopentyI)nonyl]estra-1,3,5(10)-triene-3,17?-diol, a precursor of steroids with hormonal activity which include Fulvestrant.