20583-78-2

Basic information

• Product Name: ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE
• Synonyms: ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE
• CAS NO: 20583-78-2
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.26
• Mol File: 20583-78-2.mol
• Article Data: 59

Chemical Properties

• Melting Point: 52 °C
• Boiling Point: 353.3 °C at 760 mmHg
• Flash Point: 155.2 °C
• Appearance: /
• Density: 1.099 g/cm³
• Vapor Pressure: 3.61E-05mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE(20583-78-2)
• EPA Substance Registry System: ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE(20583-78-2)

Safety Data

• Hazardous Substances Data: 20583-78-2(Hazardous Substances Data)

Usage

General Description

ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE is a chemical compound with the molecular formula C13H16O4. It is an ester derived from acrylic acid and is commonly used in the production of polymers, adhesives, and coatings. The compound is a clear, colorless liquid with a pleasant fruity odor, and it is primarily used as a fragrance ingredient in various personal care and household products. ETHYL 3-(3,4-DIMETHOXYPHENYL)ACRYLATE is also known for its potential as a monomer for the synthesis of cross-linking monomers, which are used in the production of high-performance polymers. However, careful handling and proper safety precautions should be observed when working with this chemical due to its potential health hazards and adverse effects if not used properly.

InChI:InChI=1/C13H16O4/c1-4-17-13(14)8-6-10-5-7-11(15-2)12(9-10)16-3/h5-9H,4H2,1-3H3/b8-6+

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 140-88-5 ethyl acrylate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 141-78-6 ethyl acetate 
• 121-33-5 vanillin 
• 105-36-2 ethyl bromoacetate 
• 4046-02-0 ethyl 4-hydroxy-3-methoxycinnamate 
• 74-88-4 methyl iodide 
• 133505-33-6 carbethoxymethyldibutyltelluronium bromide 
• 64-17-5 ethanol 
• 141-82-2 malonic acid 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 31930-36-6 ethyl (Z)-3-iodopropenoate 
• 2859-78-1 4-Bromoveratrole 

Downstream Products

• 144223-81-4 5,7-dihydroxy-4-(3,4-dihydroxyphenyl)-chromen-2-one 
• 22511-06-4 3,4-dimethoxyphenylpropiolic acid 
• 3929-47-3 3-(3,4-dimethoxyphenyl)-1-propanol 

Relevant articles and documents

Electrochemical reduction of a bromo propargyloxy ester at silver cathodes in dimethylformamide

Cyclic voltammograms for the reduction of ethyl 2-bromo-3-(3',4'-dimethoxyphenyl)-3-(propargyloxy)propanoate (1) at a silver cathode in dimethylformamide (DMF) containing 0.10 M tetraethylammonium tetrafluoroborate (TEABF4) exhibit several cathodic peaks,

Synthesis, in vitro cytotoxicity, and molecular docking study of novel 3,4-dihydroisoquinolin-1(2H)-one based piperlongumine analogues

With the aim of expanding the scope of SAR on piperlongumine (PL), a naturally occurring anticancer molecule, we have designed a novel hybrid molecule bearing 3,4-dihydroisoquinolin-1(2H)-one and trans-cinnamic acids. The structure, based on hybridization strategy, is used for hybridization of naturally occurring scaffolds. We have synthesized 14 hybrid molecules by coupling 3,4-dihydroisoquinolin-1(2H)-one core with cinnamic acids using the mix anhydride approach. The newly synthesized inhibitors were evaluated for cell viability against breast cancer MCF-7 and cervical cancer HeLa cell lines. Furthermore, the active compounds were screened for their potential in breast cancer MDA-MB-231, cervical cancer C33A cell lines, prostate cancer DU-145, PC-3, and normal VERO cells. From the series, compound 10g was seen to inhibit MCF-7 cell growth significantly with GI50 50 = 20 μM) and C33A (GI50 = 3.2 μM). While the inhibitor 10i inhibits MCF-7 breast cancer cell growth GI50 = 3.42 μM along with inhibition of cell growth in MDA-MB-231 (GI50 = 30 μM), HeLa (GI50 = 7.67 μM), C33A (GI50 = 13 μM), DU-145 (GI50 = 6.45 μM), PC-3 (GI50 = 8.68 μM), and VERO (GI50 = 2.93 μM), respectively. Furthermore, molecular docking study demonstrated these compounds could bind tightly to the colchicine domain of tubulin through a network of favorable steric and electrostatic interactions and thus act as a tubulin polymerization inhibitor.

Hypervalent iodine(iii) induced oxidative olefination of benzylamines using Wittig reagents

We have developed hypervalent iodine(iii) induced oxidative olefination of primary and secondary benzylamines using 2C-Wittig reagents, which provides easy access to α,β-unsaturated esters. Mild reaction conditions, good to excellent yields with high (E) selectivity, and a broad substrate scope are the key features of this reaction. We have successfully carried out the gram-scale synthesis of α,β-unsaturated esters.