148809-28-3

Basic information

• Product Name: (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester
• Synonyms: (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester;2,4-Dideoxy-3,5-O-(1-Methylethylidene)-L-erythro-hexonic Acid 1,1-DiMethylethyl Ester
• CAS NO: 148809-28-3
• Molecular Formula: C13H24O5
• Molecular Weight: 260
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 148809-28-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.030±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Ethyl Acetate, Methanol
• PKA: 14.25±0.10(Predicted)
• CAS DataBase Reference: (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester(148809-28-3)
• EPA Substance Registry System: (4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester(148809-28-3)

Safety Data

• Hazardous Substances Data: 148809-28-3(Hazardous Substances Data)

Usage

Chemical Properties

(4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester is Pale Yellow Oil

Uses

(4S,6R)-6-HydroxyMethyl-2,2-diMethyl-1,3-dioxane-4-acetic Acid, 1,1-DiMethylethyl Ester is a useful synthetic intermediate.

Upstream product

• 1044518-94-6 tert-butyl 2-((4S,6R)-6-[(tert-butyl)dimethylsilyloxymethyl]-2,2-dimethyl-1,3-dioxan-4-yl)acetate 

Downstream Products

• 1044518-75-3 (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester 

Relevant articles and documents

Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs

The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β-hydroxy ketone.

Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing

(Chemical Presented) A modular strategy for the assembly of amphotericin B analogues with modifications in the macrolactone ring relies on the efficient gram-scale synthesis of all major and minor motifs of amphotericin B. Proof of concept has been achieved by the preparation of the 35-deoxy aglycone en route to the long-sought-after 35-deoxy analogue of amphotericin B.