148835-24-9

Upstream product

• 148835-22-7 8-Chloro-4-((S)-1-phenyl-ethyl)-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one 
• 148905-77-5 (+)-(4AR)-(10BR)-8-chloro-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 148835-23-8 (6-Chloro-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 
• 17556-18-2 6-chloro-3,4-dihydro-1H-naphthalen-2-one 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 146117-78-4 (+)-LY191704 

Relevant academic research and scientific papers

Process for the preparation of benzo (F) quinolinones

This invention relates to a process for the preparation of hexa- and octahydrobenzo[f]quinolin-3-ones.

Synthesis of the individual enantiomers of the benzoquinolinone human type 1 steroid 5-α-reductase inhibitors LY191704 and LY266111

The first syntheses of the individual enantiomers of the benzoquinolinone class of selective inhibitors of human Type 1 steroid 5-α-reductase are described. For benzoquinolinones lacking an angular substituent, the approach relies upon an enamine acryloyl