148839-44-5Relevant articles and documents
COMBINED DIRECTED METALATION-CROSS COUPLING STRATEGIES. A REGIOSPECIFIC ROUTE TO HETERORING-ANNELATED ortho-NAPHTHOQUINONES AND A SHORT SYNTHESIS OF β-LAPACHONE
Brandao, Marcos A. F.,Oliveira, Alaide Braga de,Snieckus, Victor
, p. 2437 - 2440 (2007/10/02)
A general combined metalation-cross coupling methodology (Scheme 1) for the regiospecific construction of heteroring fused o-naphthoquinones 8 is described and its application to a short synthesis of the antimalarial/antitumor natural product β-lapachone (14) is demonstrated.