1488930-52-4Relevant academic research and scientific papers
Efficient room-temperature synthesis and antimicrobial study of novel 2-aroylbenzofuran-3-ols from substituted methyl salicylates and phenacyl bromides
Kulkarni, Rashmi S.,Hanumanthappa, Suresha Kumara T.,Gopalpur, Nagendrappa,Vijaya Kumar, Sowmya H. B.,More, Sunil S.
supporting information, p. 331 - 339 (2014/01/06)
The article describes a convenient and efficient synthetic route for the construction of 2-aroylbenzofuran-3-ols from readily available diverse methyl salicylates and phenacyl bromides using K2CO3 as catalyst in dimethylformamide as solvent at room temperature. The reaction involves two steps, which occur in quick succession within 1 h to deliver the product with reasonably high yields. All the synthesized 2-aroylbenzofuran-3-ols (4a-u) were subjected for their antimicrobial studies, and some of these have shown prominent activity. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
