1489016-24-1

Basic information

• Product Name: 3-(4-chlorophenyl)-4-nitrobutanal
• Synonyms: 3-(4-chlorophenyl)-4-nitrobutanal
• CAS NO: 1489016-24-1
• Molecular Weight: 227.647
• Mol File: 1489016-24-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-4-nitrobutanal(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-4-nitrobutanal(1489016-24-1)
• EPA Substance Registry System: 3-(4-chlorophenyl)-4-nitrobutanal(1489016-24-1)

Safety Data

• Hazardous Substances Data: 1489016-24-1(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 1075-77-0 4-chlorocinnamaldehyde 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 75-07-0 acetaldehyde 
• 1075-77-0 (E)-4-chlorocinnamic aldehyde 

Downstream Products

• 159112-23-9 3-(4-chlorophenyl)-4-nitrobutanoic acid 
• 101466-69-7 methyl (+/-)-3-(4-chlorophenyl)-4-nitrobutanoate 
• 1140518-42-8 C₁₀H₁₂ClNO₃ 
• 1402406-55-6 (R)-3-(4-chlorophenyl)-4-nitrobutan-1-ol 

Relevant articles and documents

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram scale. The telescoped process comprises an enantioselective Michael-type add

Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes

Call me Michaelase: The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to a collection of aromatic and aliphatic nitroolefins with high stereoselectivity producing precursors of γ-aminobutyric

Water-compatible iminium activation: Organocatalytic Michael reactions of carbon-centered nucleophiles with enals

(Chemical Equation Presented) A pool of water-compatible catalysts, namely the chiral prolinol-based catalysts 1, has been developed for highly enantioselective C-C bond-forming Michael reactions in water (see scheme). The synthesis of (S)-Rolipram, a type IV phosphodiesterase inhibitor, was also demonstrated.