148902-86-7Relevant academic research and scientific papers
Synthesis and antiparasitic activity of new 1-nitro, 1-amino and 1-acetamido 9-acridinones
Ngadi,Bsiri,Mahamoud,Galy,Galy,Soyfer,Barbe,Placidi,Rodriguez-Santiago,Mesa-Valle,Lombardo,Mascaro,Osuna
, p. 480 - 483 (2007/10/02)
The synthesis of 1-amino-10-alkyl-9-acridinones 4 and 5 and of homologous 9-thio-acridinones 7 and 8 are described. Similarly, the synthesis of 1-nitro-4-(2'-aminoethylamino)-9-acridinones 13 and 15, is described. Compound 4 was used as starting material for the preparation of 10-alkyl-9-acridinone dimers 6, bridged with an α,ω-diamido chain. Compound 15 was selected for biological investigations on pathogenic parasite strains, and a promising antiamoebic activity could be shown.
Some new 1-nitro acridine derivatives as antimicrobial agents
Ngadi,Galy,Galy,Barbe,Cremieux,Chevalier,Sharples
, p. 67 - 70 (2007/10/02)
Some new 1-nitro acridine derivatives were prepared and characterized. These compounds were screened for evaluating their antimicrobial properties against Gram+ bacteria, Gram- bacteria, and mycobacteria as well as fungi. With reference to the results obtained, 1-nitro-4-aminoethylamine-9-alkylthioacridines must be considered as promising lead molecules.
