14891-10-2

Basic information

• Product Name: 1-N-Ethoxycarbonyl-3-pyrrolidone
• Synonyms: 1-N-ETHOXYCARBONYL-3-PYRROLIDONE;3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID ETHYL ESTER;N-(Ethoxy carboNyl)-3-pyrrolidoNe;1-ETHOXYCARBONYL-3-PYRROLIDONE;1-Ethoxycabonyl-3-Pyrrolidone;ethyl 3-oxopyrrolidine-1-carboxylate;Ethyl 3-oxopyrrolidine-1-...;1-Boc-3-Oxopyrrolidine
• CAS NO: 14891-10-2
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 14891-10-2.mol

Chemical Properties

• Boiling Point: 255.2 °C at 760 mmHg
• Flash Point: 108.1 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 0.0165mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 1-N-Ethoxycarbonyl-3-pyrrolidone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-Ethoxycarbonyl-3-pyrrolidone(14891-10-2)
• EPA Substance Registry System: 1-N-Ethoxycarbonyl-3-pyrrolidone(14891-10-2)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 14891-10-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-N-Ethoxycarbonyl-3-pyrrolidone is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and reactivity make it a valuable component in the development of new pharmaceutical compounds, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 1-N-Ethoxycarbonyl-3-pyrrolidone serves as a key intermediate in the production of agrochemicals. Its ability to participate in various organic reactions facilitates the synthesis of effective and targeted agrochemicals, enhancing crop protection and yield.
Used as a Solvent in Industrial Processes:
1-N-Ethoxycarbonyl-3-pyrrolidone is utilized as a solvent in a wide range of industrial applications. Its solubility properties and stability make it suitable for dissolving various substances, enabling efficient processes in different industries.
Used in Organic Synthesis:
As a versatile chemical, 1-N-Ethoxycarbonyl-3-pyrrolidone is employed as a precursor to synthesize other compounds in organic synthesis. Its reactivity and functional groups allow for the formation of diverse chemical entities, expanding the scope of organic chemistry and contributing to the discovery of new materials and compounds.

InChI:InChI=1/C7H11NO3/c1-2-11-7(10)8-4-3-6(9)5-8/h2-5H2,1H3

Upstream product

• 130482-76-7 5-(Hydroxy-phenyl-methyl)-4-oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester 

Downstream Products

• 96-42-4 pyrrolidin-3-one 
• 13220-33-2 1-methyl-3-pyrrolidinol 
• 93591-91-4 ethyl 3-hydroxypyrrolidine-1-carboxylate 
• 62869-46-9 1,4-dithia-7-aza-spiro[4.4]nonane-7-carboxylic acid ethyl ester 
• 34086-69-6 6,7-Methylendioxypyrrolochinolin (19) 
• 83925-25-1 (+/-)-2(R^*)-<3(R^*)-<4-(benzyloxy)but-1-enyl>>-1-(ethoxycarbonyl)pyrrolidin-3-one 
• 92041-82-2 ethyl 3-hydroxy-3-phenyl-1-pyrrolidinecarboxylate 
• 26862-71-5 ethyl 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-2-carboxylate 
• 476159-75-8 ethyl 3-hydroxy-3-(2-naphthyl)-1-pyrrolidinecarboxylate 
• 94311-44-1 ethyl 3-(4-biphenylyl)-3-hydroxy-1-pyrrolidinecarboxylate 
• 92502-10-8 ethyl 3-hydroxy-3-(4-methoxyphenyl)-1-pyrrolidinecarboxylate 
• 476159-73-6 ethyl 3-[4-(dimethylamino)phenyl]-3-hydroxy-1-pyrrolidinecarboxylate 
• 96431-51-5 3-(4-chloro-phenyl)-3-hydroxy-pyrrolidine-1-carboxylic acid ethyl ester 
• 929083-47-6 C₁₃H₁₂F₅NO₃ 

Relevant articles and documents

β-Ketoester Dianions as Regiospecific Enolate Equivalents for N-Substituted Pyrrolidin-3-ones

Double deprotonation of β-ketoester (6) gives dianion (7) which serves as a synthetic equivalent of the regiospecific ketone enolate (3), providing a synthetic entry to 2-substituted pyrrolidin-3-ones (9) and (10).