83455-93-0

Upstream product

• 14891-08-8 N-ethoxycarbonyl-N-ethoxycarbonylmethyl-β-alanine ethyl ester 
• 83455-91-8 (+/-)-1-(ethoxycarbonyl)-2-(prop-1-en-3-yl)pyrrolidin-3-one 
• 14891-10-2 ethyl-3-oxo-1-pyrrolidinecarboxylate 
• 100-39-0 benzyl bromide 
• 83455-92-9 (+/-)-1-(ethoxycarbonyl)-3β-hydroxy-2β-(prop-1-en-3-yl)pyrrolidine 

Downstream Products

• 86971-19-9 (+/-)-3β-(benzyloxy)-2β-(prop-1-en-3-yl)pyrrolidine 

Relevant academic research and scientific papers

Novel Synthesis of the Pyrrolizidine Skeleton by Sulfenocycloamination. Total Synthesis of (+/-)-Retronecine and (+/-)-Turneforcidine

The ω-unsaturated amines 1, 6, and 7 were converted into pyrrolidines 4 and 8 and piperidine 9, respectively, by treatment of their hydrochlorides with benzenesulfenyl chloride followed by base-induced ring closure.This novel sulfenocycloamination ring closure was applied to the synthesis of the pyrrolizidine ring (e.g., 20) and to the total synthesis of (+/-)-retronecine (32) and (+/-)-turneforcidine (34).

A NOVEL AND STEREOSELECTIVE SYNTHESIS OF CIS-1-8-H-HYDROXYPYRROLIZIDINE

The title compound was synthesized through a regioselective introduction of allyl group at the C2 position of the 3-oxopyrrolidine derivative (2) by sigmatropic rearrangement and an amino cyclization via the episulfonium intermediate (8)