148927-13-3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 314-41-0 1,2,3,5-tetrafluoro-4-nitrobenzene 

Downstream Products

• 161040-89-7 2-({Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amino}-methylene)-malonic acid diethyl ester 
• 161040-94-4 5,6-Diamino-8-benzylsulfanyl-1-cyclopropyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester 
• 161040-86-4 Cyclopropyl-[2,5-difluoro-3-(4-methyl-piperazin-1-yl)-4-nitro-phenyl]-amine 

Relevant academic research and scientific papers

6-Aminoquinolones: A new class of quinolone antibacterials?

A series of quinolone- and 1,8-naphthyridone-3-carboxylic acids, designed by previous QSAR studies and characterized by an amino group at the C-6 position instead of the usual fluorine atom, were synthesized for the first time and evaluated for in vitro antibacterial activity. All of the synthesized compounds maintain good activity against Gram-negative bacteria (Pseudomonas aeruginosa excluded), and those compounds having a thiomorpholine group as the C-7 substituent also have good activity against Gram-positive bacteria. Some aspects of structure activity relationships associated with the C-1, C-5, C-7, and C-8 substituents are also discussed. Derivatives 18g and 38g displayed the best activity with geometric mean MICs of 0.45 and 0.66-0.76 μg/mL against Gram-negative and Gram-positive bacteria, respectively. This antimicrobial activity reflects their ability to inhibit bacterial DNA-gyrase. The results of this study show that, while the C-6 fluorine is still the preferred substituent, good activity can still be obtained by replacing it with an amino group.

6-Aminoquinolones, their synthesis and their use as antibacterial agents

6-aminoquinolones, fit for being used as antibacterial agents, having the following general formula: wherein X =CH, CCH3, CF, N; R1 =H, F, NH2; R2 =R3 =